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225 Minutes Week for Healthy Subjects (IGNITE Trial)

Phase 3
Waitlist Available
Led By Kirk I Erickson, PhD
Research Sponsored by University of Pittsburgh
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6 months and 12 month
Awards & highlights

IGNITE Trial Summary

This trial will examine whether a 12 month monitored exercise intervention improves brain health in cognitively normal older adults, including whether the recommended public health guidelines of 150 minutes/week of exercise are sufficient, if exercise influences brain structure and/or function, if there is a dose-response effect of exercise, what mechanisms by which exercise influences brain health, and what factors attenuate or magnify the effects of exercise.

Eligible Conditions
  • Healthy Subjects
  • Social Cognition

IGNITE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6 months and 12 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 6 months and 12 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Cognitive Function
Secondary outcome measures
Change in brain morphology (Volume)
Other outcome measures
APOE Status
Alzheimer's Disease (AD) PET amyloid
Change in Blood Pressure
+83 more

IGNITE Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: 225 Minutes WeekExperimental Treatment1 Intervention
Participants engage in supervised 12 month moderate intensity aerobic exercise intervention with goal of maintaining 225 minutes of exercise per week.
Group II: 150 Minutes WeekExperimental Treatment1 Intervention
Participants engage in supervised 12 month moderate intensity aerobic exercise intervention with goal of maintaining 150 minutes of exercise per week.
Group III: Stretch and ToneActive Control1 Intervention
Participants engage in supervised 12 month non-cardiorespiratory activity intervention. This group has focus on improving balance, flexibility, and strength.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
225 Minutes Week
2017
Completed Phase 3
~650
150 Minutes Week
2017
Completed Phase 3
~650

Find a Location

Who is running the clinical trial?

University of PittsburghLead Sponsor
1,722 Previous Clinical Trials
16,342,298 Total Patients Enrolled
National Institutes of Health (NIH)NIH
2,701 Previous Clinical Trials
7,506,228 Total Patients Enrolled
National Institute on Aging (NIA)NIH
1,675 Previous Clinical Trials
28,020,277 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available positions for volunteers in this experiment?

"This clinical trial, as reported on clinicaltrials.gov, is not currently recruiting patients. The study was originally posted on 9/6/2017 and was most recently updated on 10/4/2022. While this study is not recruiting candidates at this time, there are 895 other clinical trials presently looking for participants at this time."

Answered by AI

Are senior citizens being included in this research project?

"The minimum age for this study is 65, while the oldest a patient can be and still participate in the trial is 80."

Answered by AI

What are the governing body's thoughts on 225 Minutes Week?

"There is some data to support the efficacy of 225 Minutes Week and it has received multiple rounds of safety testing, so our team at Power gives it a 3."

Answered by AI

Am I eligible to join this clinical trial?

"In order to qualify for this study, potential participants must be aged 65-80, have no diagnosed neurological diseases, and lead a relatively sedentary lifestyle (exercising for less 20 minutes per week). Other requirements include being able to walk without pain or the need of an assistive device as well as being English literate. Living in the community for the duration of the study and having reliable transportation are also important factors. If all these conditions are met, patients will then need medical clearance from their primary care physician before finally undergoing an MRI."

Answered by AI

Who else is applying?

What state do they live in?
Missouri
Massachusetts
Kansas
How old are they?
18 - 65
What site did they apply to?
Northeastern University
University of Kansas
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
1

Why did patients apply to this trial?

What questions have other patients asked about this trial?

Yes. What measures to you take during the study? Where would the exercise take place?
PatientReceived 1 prior treatment

How responsive is this trial?

Average response time
  • < 2 Days
Typically responds via
Email
Most responsive sites:
  1. Northeastern University: < 48 hours
Recent research and studies
clinicaltrials.govStudy
Investigating Gains in Neurocognition in an Intervention Trial of Exercise
Kirk Erickson, PhD 2017. "Investigating Gains in Neurocognition in an Intervention Trial of Exercise". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02875301.
~85 spots leftby Apr 2025
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