80 Participants Needed

Multidisciplinary Team Care for Breast Cancer

(TITAN Trial)

Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: University of Alberta
Must be taking: Anthracyclines, Trastuzumab
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment Multidisciplinary team intervention for breast cancer?

Research shows that multidisciplinary team care, which involves specialists from different fields working together, can improve survival rates and patient outcomes for breast cancer. This approach helps in making better treatment decisions and managing the complexity of cancer care.12345

Is multidisciplinary team care for breast cancer safe for humans?

The studies suggest that multidisciplinary team care for breast cancer is generally safe, as it is widely accepted and valued by both patients and health professionals, without increasing patient anxiety.12367

How is the multidisciplinary team treatment for breast cancer different from other treatments?

The multidisciplinary team treatment for breast cancer is unique because it involves a group of healthcare professionals from different specialties working together to create a personalized care plan for each patient, ensuring a holistic approach to treatment. This collaborative method aims to provide seamless care across various stages of the disease, unlike traditional treatments that may not involve such comprehensive teamwork.1891011

What is the purpose of this trial?

People with breast cancer often experience many short and long-term side effects as a result of both the cancer and the necessary treatments.Receiving extra assessments and care from teams of multiple health professionals has been shown to be helpful for people with other health problems, such as heart disease. These 'multidisciplinary' teams may include nurses, doctors, pharmacists, dietitians, exercise therapists, counselors, and other specialists. Currently, the investigators do not know if receiving extra assessments from a multidisciplinary team is helpful for people receiving cancer treatment.In this study, the investigators hope to learn the effect of extra assessments and early interventions from teams of health care professionals in people diagnosed with cancer, during and after the treatment period.After initial assessments, participants will be randomized to multidisciplinary team intervention or usual care.

Eligibility Criteria

This trial is for adults over 18 with breast cancer or lymphoma, scheduled for specific chemotherapy treatments, and able to attend follow-ups. It's not for those with heart issues, prior thorax radiotherapy, previous similar chemo treatments, physical disability impeding certain tests, psychiatric conditions affecting consent, or involvement in related studies.

Inclusion Criteria

willing to attend follow-up visits.
My cancer (breast or lymphoma) has been confirmed through tissue examination.
I am scheduled for chemotherapy that includes anthracycline or trastuzumab.

Exclusion Criteria

I have had radiation therapy to my chest area before.
I have had treatments with anthracycline or trastuzumab.
I do not have heart failure, cardiomyopathy, or an LVEF below 50%.
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Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Initial Assessment

Initial assessments conducted before randomization to intervention or usual care

1-2 weeks

Treatment

Participants receive either multidisciplinary team intervention or usual care

12 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Multidisciplinary team intervention
Trial Overview The TITAN Study is testing whether extra care from a team of various health professionals (like nurses and dietitians) can benefit people with cancer during and after treatment. Participants will be randomly assigned to receive either this multidisciplinary intervention or the usual care.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: multidisciplinary team interventionExperimental Treatment1 Intervention
Intervention arm receives regular assessments and treatments from cardiology team, clinical nutrition, pharmacist, exercise physiologist and physiotherapist
Group II: Observational armActive Control1 Intervention
Participants randomized to observational arm will receive usual care.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Alberta

Lead Sponsor

Trials
957
Recruited
437,000+

References

Effects of multidisciplinary team working on breast cancer survival: retrospective, comparative, interventional cohort study of 13 722 women. [2022]
Analysing Breast Cancer Multidisciplinary Patient Management: A Prospective Observational Evaluation of Team Clinical Decision-Making. [2020]
Does multidisciplinary care enhance the management of advanced breast cancer?: evaluation of advanced breast cancer multidisciplinary team meetings. [2021]
Benefits of multidisciplinary teamwork in the management of breast cancer. [2022]
Surgical leadership and standardization of multidisciplinary breast cancer care: the evolution of the National Accreditation Program for Breast Centers. [2014]
Communication skills training for breast cancer teams talking about trials. [2015]
A pilot study to evaluate the impact of involving breast cancer patients in the multidisciplinary discussion of their disease and treatment plan. [2022]
Multidisciplinary team working: is it both holistic and effective? [2018]
Compliance with multidisciplinary team recommendations and disease outcomes in early breast cancer patients: An analysis of 4501 consecutive patients. [2021]
Multidisciplinary decisions in breast cancer: does the patient receive what the team has recommended? [2022]
Multidisciplinary Team Meeting Proposal and Final Therapeutic Choice in Early Breast Cancer: Is There an Agreement? [2022]
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