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Antiprogestin

Mifepristone for Vaginal Birth After Cesarean (VBAC) (MiLI Trial)

Phase 3
Waitlist Available
Led By Kate Shaw, MD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 1 minute and 5 minutes of infant life (approximately 10 seconds to perform each assessment)
Awards & highlights

MiLI Trial Summary

This trial is testing whether mifepristone can help induce labor and reduce the time spent in labor.

MiLI Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 1 day post-partum, up to approximately 15 minutes to complete the survey
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 1 day post-partum, up to approximately 15 minutes to complete the survey for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean neonatal APGAR scores from 0-10
Mean neonatal arterial cord blood pH
Measured number of total minutes of uterine tachysystole or hypertonus per hour from the time of medication administration until the time of delivery
+8 more
Secondary outcome measures
Composite of serious maternal morbidity or death
Composite of serious neonatal morbidity or perinatal death
Neonatal APGAR scores from 0-10
+9 more

MiLI Trial Design

2Treatment groups
Active Control
Group I: MifepristoneActive Control1 Intervention
Participants will be given mifepristone with insertion of the cervical Cook balloon for labor induction
Group II: MisoprostolActive Control1 Intervention
Participants will be given misoprostol with insertion of the cervical Cook balloon for labor induction

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,394 Previous Clinical Trials
17,341,580 Total Patients Enrolled
Kate Shaw, MDPrincipal InvestigatorStanford University
1 Previous Clinical Trials
80 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the potential dangers of taking Mifepristone?

"Mifepristone's safety is supported by efficacy data, so it received a 3."

Answered by AI

How can I sign up to participate in this experiment?

"This study is looking for 30 participants who: are between 18-45 years old, have an induced vaginal delivery, are pregnant, carrying a single fetus, nulliparous (no prior births), gestational age of 37 weeks to 42 weeks, cephalic presentation, admitted for labor induction but not currently in labor, no contraindications for mifepristone or vaginal delivery, and have a Bishop score <6."

Answered by AI

Will this clinical trial be testing elderly individuals?

"The age range for participants in this clinical trial is 18-45 years old."

Answered by AI

What is the existing data on Mifepristone's efficacy?

"Presently, 10 studies are underway that involve Mifepristone. Out of those 10 ongoing investigations, 2 have reached Phase 3. Most of the research is based in New york City but 32 different locations across America are running these trials."

Answered by AI

Are there any open vacancies for this clinical trial?

"This particular trial is no longer looking for new patients. The study was posted on June 27th, 2020 and updated on the same day; however, there are other trials with similar procedures that are still enrolling participants."

Answered by AI

What are the most popular applications for Mifepristone?

"Mifepristone can be used to therapeutically treat procedures, hyperglycemia, and medically induced abortions."

Answered by AI

How many people are being given the chance to participate in this research?

"Currently, this study is not in the process of recruiting patients. This trial was posted on June 27th, 2022 and was last edited on the same day. However, if you are looking for similar trials, there are 3 induced vaginal delivery studies and 10 Mifepristone clinical trials that are presently searching for candidates."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Mifepristone for Labor Induction
Kate Ayers Shaw 2022. "Mifepristone for Labor Induction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05097326.
~11 spots leftby Apr 2025
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