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PENG Block for Total Hip Replacement ((PENG) Trial)

Phase 3
Waitlist Available
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours after surgery
Awards & highlights

(PENG) Trial Summary

This trial is testing whether a new type of block (PENG) is better than no block at reducing pain and improving quality of recovery after hip replacement surgery.

(PENG) Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours after surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours after surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Recovery After Total Hip Arthroplasty
Secondary outcome measures
Ambulation Distance After Surgery
Average Pain Medicine Required After Surgery.
Evaluating Recovery After Total Hip Arthroplasty
+2 more

(PENG) Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Investigational group ("PENG Block" group)Experimental Treatment1 Intervention
Participants in the pericapsular nerve group block (PENG) arm will receive a PENG block preoperatively in the block area placed under direct ultrasound guidance as follows: Parenteral midazolam and fentanyl will be titrated to patient comfort. Standard skin sterilization, prepping and draping will be applied to the area Anatomical landmarks identified using ultrasound and skin will be numbed using 2-3 cc of 2% lidocaine. Long acting local anesthetic, a bolus of 25 cc of 0.5 % Bupivacaine will be injected lateral to iliopubic eminence (IPE). A Curvilinear low frequency (2-5 MHz) ultrasound probe will be used to identify landmarks. A 22 G, 10 cm needle will be inserted using in-plane technique and advanced to target site (17).
Group II: Control groupActive Control1 Intervention
Control group participants will be transferred to the block area preoperatively, and care will proceed as if they were receiving injection. Patients will be placed in the supine position resting comfortably. Standard noninvasive monitors will be applied, and oxygen will be administered via nasal cannula. Parenteral midazolam and fentanyl will be titrated to patient comfort. Standard skin sterilization, prepping and draping will be applied to the area. The ultrasound probe will be used to identify the iliopubic eminence (IPE). Only skin will be numbed using 2-3 cc of 2% lidocaine and NO bolus of bupivacaine will be injected.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PENG Block
2022
Completed Phase 3
~400

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,574 Previous Clinical Trials
2,273,235 Total Patients Enrolled
Shana GravesStudy DirectorUAB shannagraves@uabmc.edu

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are some of the more popular conditions that PENG Block helps ease?

"PENG Block has been used to effectively treat cervical syndrome, minor burns, and even transplant patients."

Answered by AI

Are there any know risks associated with PENG Block usage?

"PENG Block is considered safe according to our team's 3-point scale. This is due to the fact that Phase 3 trials have provided some evidence of efficacy as well as multiple rounds of data supporting safety."

Answered by AI

How many people are the researchers testing this medication on?

"That is correct, the clinicaltrials.gov website has information stating that this study is still searching for volunteers. The trial was first posted on February 1st, 2021 and was updated as recently as July 14th, 2022. They are looking for 100 individuals total at 1 location."

Answered by AI

What is the scientific literature on PENG Block's efficacy?

"At the moment, 135 research projects are underway to study PENG Block. Among these studies, 34 are in Phase 3. Many of the PENG Block studies are based in Calgary, Alberta; however, there are 1083 total research locations for this treatment."

Answered by AI

Are there any positions open for participants in this research?

"The information available on clinicaltrials.gov reveals that this clinical trial is still recruiting patients. The listing was first posted on February 1st, 2021 and was updated as recently as July 14th, 2022."

Answered by AI

Who else is applying?

What state do they live in?
Alabama
How old are they?
18 - 65
What site did they apply to?
University of Alabama at Birmingham
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Trial Comparing Impact of PENG Block on Quality of Recovery Compared to No-block for Primary Total Hip Arthroplasty
Promil Kukreja 2021. "Trial Comparing Impact of PENG Block on Quality of Recovery Compared to No-block for Primary Total Hip Arthroplasty". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04591353.
~29 spots leftby Apr 2025
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