Study Summary
This trialwill study the effect of different exercise intensities on brain blood flow and cognition in elderly people. It will help find the best exercise for seniors to protect against age-related mental decline.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 6 Secondary · Reporting Duration: 4 individual measurements taken during each experimental session with each session lasting up to about 3 hours. 1 pre-intervention measurement and 3 post-intervention measurements spaced at least 15min apart
Hour 3
Vascular Endothelial Growth Factor (VEGF)
Hour 3
Brain-Derived Neurotrophic Factor (BDNF)
Hour 3
Augmentation Index (AI)
Internal Carotid Artery (ICA) Diameter
Internal Carotid Artery (ICA) Distensibility
Internal Carotid Artery (ICA) Pulse Velocity
Pulse Wave Velocity (Brachial-Femoral)
Working Memory
Hour 3
End Tidal CO2 (ETCO2)
Heart Rate
Mean Arterial Pressure (MAP)
Middle Cerebral Artery Velocity (MCAv)
Pre-frontal Hemoglobin Oxygen Saturation
Trial Safety
Safety Progress
Trial Design
3 Treatment Groups
Control
1 of 3
Acute bout of Continuous Moderate Intensity Exercise
1 of 3
Acute bout of High Intensity Interval Training (HIIT)
1 of 3
Experimental Treatment
16 Total Participants · 3 Treatment Groups
Primary Treatment: Acute bout of High Intensity Interval Training · No Placebo Group · N/A
Control
Other
Experimental Group · 1 Intervention: Control · Intervention Types: OtherAcute bout of Continuous Moderate Intensity Exercise
Other
Experimental Group · 1 Intervention: Acute bout of Continuous Moderate Intensity Exercise · Intervention Types: OtherAcute bout of High Intensity Interval Training (HIIT)
Other
Experimental Group · 1 Intervention: Acute bout of High Intensity Interval Training · Intervention Types: OtherTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 4 individual measurements taken during each experimental session with each session lasting up to about 3 hours. 1 pre-intervention measurement and 3 post-intervention measurements spaced at least 15min apart
Who is running the clinical trial?
University of VirginiaLead Sponsor
694 Previous Clinical Trials
1,467,446 Total Patients Enrolled
Jason Allen, PhDPrincipal InvestigatorUniversity of Virginia
2 Previous Clinical Trials
124 Total Patients Enrolled
Eligibility Criteria
Age 65+ · All Participants · 5 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:References
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- Weaver SR, Skinner BD, Furlong R, Lucas RAI, Cable NT, Rendeiro C, McGettrick HM, Lucas SJE. Cerebral Hemodynamic and Neurotrophic Factor Responses Are Dependent on the Type of Exercise. Front Physiol. 2021 Jan 21;11:609935. doi: 10.3389/fphys.2020.609935. eCollection 2020. Erratum in: Front Physiol. 2021 Feb 24;12:659873.
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- Fan JL, Nogueira RC, Brassard P, Rickards CA, Page M, Nasr N, Tzeng YC. Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke. J Cereb Blood Flow Metab. 2022 Mar;42(3):454-470. doi: 10.1177/0271678X211033732. Epub 2021 Jul 26. Review.
- Ogoh S, Tsukamoto H, Hirasawa A, Hasegawa H, Hirose N, Hashimoto T. The effect of changes in cerebral blood flow on cognitive function during exercise. Physiol Rep. 2014 Sep 28;2(9):e12163. doi: 10.14814/phy2.12163. Print 2014 Sep 1.
- Gonzalez-Alonso J, Dalsgaard MK, Osada T, Volianitis S, Dawson EA, Yoshiga CC, Secher NH. Brain and central haemodynamics and oxygenation during maximal exercise in humans. J Physiol. 2004 May 15;557(Pt 1):331-42. doi: 10.1113/jphysiol.2004.060574. Epub 2004 Mar 5.
- Fulesdi B, Limburg M, Bereczki D, Kaplar M, Molnar C, Kappelmayer J, Neuwirth G, Csiba L. Cerebrovascular reactivity and reserve capacity in type II diabetes mellitus. J Diabetes Complications. 1999 Jul-Aug;13(4):191-9. doi: 10.1016/s1056-8727(99)00044-6.
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- Alexandrov AV, Sloan MA, Wong LK, Douville C, Razumovsky AY, Koroshetz WJ, Kaps M, Tegeler CH; American Society of Neuroimaging Practice Guidelines Committee. Practice standards for transcranial Doppler ultrasound: part I--test performance. J Neuroimaging. 2007 Jan;17(1):11-8. doi: 10.1111/j.1552-6569.2006.00088.x.
- Keating CJ, Parraga Montilla JA, Latorre Roman PA, Moreno Del Castillo R. Comparison of High-Intensity Interval Training to Moderate-Intensity Continuous Training in Older Adults: A Systematic Review. J Aging Phys Act. 2020 Apr 16:1-10. doi: 10.1123/japa.2019-0111. Online ahead of print.
- Loe H, Rognmo O, Saltin B, Wisloff U. Aerobic capacity reference data in 3816 healthy men and women 20-90 years. PLoS One. 2013 May 15;8(5):e64319. doi: 10.1371/journal.pone.0064319. Print 2013. Erratum In: PLoS One. 2013;8(11). doi:10.1371/annotation/e3115a8e-ca9d-4d33-87ef-f355f07db28e.
- Fan JL, Nogueira RC, Brassard P, Rickards CA, Page M, Nasr N, Tzeng YC. Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke. J Cereb Blood Flow Metab. 2022 Mar;42(3):454-470. doi: 10.1177/0271678X211033732. Epub 2021 Jul 26.
- Jones RD, Hugh Jones T, Channer KS. The influence of testosterone upon vascular reactivity. Eur J Endocrinol. 2004 Jul;151(1):29-37. doi: 10.1530/eje.0.1510029.
- Ogoh S, Ainslie PN. Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol (1985). 2009 Nov;107(5):1370-80. doi: 10.1152/japplphysiol.00573.2009. Epub 2009 Sep 3.
- Smith KJ, Ainslie PN. Regulation of cerebral blood flow and metabolism during exercise. Exp Physiol. 2017 Nov 1;102(11):1356-1371. doi: 10.1113/EP086249. Epub 2017 Sep 30.
- Settakis G, Lengyel A, Molnar C, Bereczki D, Csiba L, Fulesdi B. Transcranial Doppler study of the cerebral hemodynamic changes during breath-holding and hyperventilation tests. J Neuroimaging. 2002 Jul;12(3):252-8.
- Calverley TA, Ogoh S, Marley CJ, Steggall M, Marchi N, Brassard P, Lucas SJE, Cotter JD, Roig M, Ainslie PN, Wisloff U, Bailey DM. HIITing the brain with exercise: mechanisms, consequences and practical recommendations. J Physiol. 2020 Jul;598(13):2513-2530. doi: 10.1113/JP275021. Epub 2020 Jun 1.
- Shephard RJ. Maximal oxygen intake and independence in old age. Br J Sports Med. 2009 May;43(5):342-6. doi: 10.1136/bjsm.2007.044800. Epub 2008 Apr 10.
- Ogoh S. Relationship between cognitive function and regulation of cerebral blood flow. J Physiol Sci. 2017 May;67(3):345-351. doi: 10.1007/s12576-017-0525-0. Epub 2017 Feb 3.
- Weaver SR, Skinner BD, Furlong R, Lucas RAI, Cable NT, Rendeiro C, McGettrick HM, Lucas SJE. Cerebral Hemodynamic and Neurotrophic Factor Responses Are Dependent on the Type of Exercise. Front Physiol. 2021 Jan 21;11:609935. doi: 10.3389/fphys.2020.609935. eCollection 2020. Erratum In: Front Physiol. 2021 Feb 24;12:659873.
- Lie SL, Hisdal J, Hoiseth LO. Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers. Eur J Appl Physiol. 2021 Aug;121(8):2207-2217. doi: 10.1007/s00421-021-04693-6. Epub 2021 Apr 22.
- Olivo G, Nilsson J, Garzon B, Lebedev A, Wahlin A, Tarassova O, Ekblom M, Lovden M. Immediate effects of a single session of physical exercise on cognition and cerebral blood flow: A randomized controlled study of older adults. Neuroimage. 2021 Jan 15;225:117500. doi: 10.1016/j.neuroimage.2020.117500. Epub 2020 Oct 24.
- Belfort MA, Saade GR, Snabes M, Dunn R, Moise KJ Jr, Cruz A, Young R. Hormonal status affects the reactivity of the cerebral vasculature. Am J Obstet Gynecol. 1995 Apr;172(4 Pt 1):1273-8. doi: 10.1016/0002-9378(95)91492-7.
- Jason Allen 2022. "Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05131217.
Frequently Asked Questions
How extensive is the participant pool in this clinical trial?
"Affirmative. According to clinicaltrials.gov, this investigation was first posted on the 14th of January 2022 and is still actively recruiting participants. This trial requires 16 volunteers from a single medical centre." - Anonymous Online Contributor
Unverified Answer
Are there any opportunities for new participants to join this experiment?
"Affirmative. According to the data accessible on clinicaltrials.gov, this research endeavour is actively recruiting participants. It was initially posted on January 14th 2022 and subsequently modified November 4th of that same year. 16 individuals are being sought from a single medical centre for participation in the study." - Anonymous Online Contributor
Unverified Answer