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Probiotic

Probiotics treatment on midazolam and acetaminophen metabolism for Metabolism

N/A
Waitlist Available
Led By Yvonne Lin, PhD
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0 to 12 hours on days 1 and 29
Awards & highlights

Study Summary

This trial will study the effects of probiotic supplementation on drug, vitamin, and hormone metabolism.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0 to 12 hours on days 1 and 29
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 to 12 hours on days 1 and 29 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Acetaminophen area under the curve (AUC)
Acetaminophen peak concentration (Cmax)
Acetaminophen-glucuronide area under the curve (AUC)
+5 more
Secondary outcome measures
Acetaminophen
Midazolam terminal half-life
Urinary excretion of 1'-hydroxymidazolam
+2 more
Other outcome measures
Microbiome composition of fecal sample

Trial Design

1Treatment groups
Experimental Treatment
Group I: Probiotics treatment on midazolam and acetaminophen metabolismExperimental Treatment1 Intervention
Experimental: Day 1: midazolam (2 mg oral) + acetaminophen (500 mg oral) + midazolam (1 mg IV) Days 1-28: Visbiome (2 capsules) administered BID Day 11: midazolam (2 mg oral) + acetaminophen (500 mg oral) + midazolam (1 mg IV)

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,740 Previous Clinical Trials
1,847,688 Total Patients Enrolled
Yvonne Lin, PhD4.5296 ReviewsPrincipal Investigator - University of Washington
Medical School - State University of New York, Downstate Medical Center, Doctor of Medicine
1 Previous Clinical Trials
16 Total Patients Enrolled
1Patient Review
My time and money would have been better spent elsewhere. I went in for an allergy test, and instead received a fruitless biopsy that left me with an unsightly scar. The P.A. who called me with my results was unsure of what they were, and said I'd have to come back for another blood test. To top it all off, my hives are still here. I'll only be back when (and if) Dr. Lin can figure out what's going on.

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Impact of Probiotics on Drug, Vitamin, and Hormone Metabolism
Yvonne Lin 2020. "Impact of Probiotics on Drug, Vitamin, and Hormone Metabolism". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04281407.
~2 spots leftby Apr 2025
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