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Behavioural Intervention

Minimal to No Respiratory Weakness for Lou Gehrig's Disease

N/A
Waitlist Available
Led By Harrison Jones, PhD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 7 weeks, 18 weeks, 24 weeks
Awards & highlights

Study Summary

This trial will study the effects of progressive respiratory muscle training in adults with ALS. Participants will be stratified into two groups based on their baseline inspiratory muscle strength, and the investigators will measure maximum inspiratory pressure and maximum expiratory pressure weekly.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 7 weeks, 18 weeks, 24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 7 weeks, 18 weeks, 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Magnitude of Change in Maximum Expiratory Pressure from Baseline to Withdrawal
Magnitude of Change in Maximum Expiratory Pressure from Pre-test to Post-test
Magnitude of Change in Maximum Inspiratory Pressure from Pre-test to Post-test
+2 more
Secondary outcome measures
Change in Peak Cough Flow in L/min
Change in Sniff Nasal Inspiratory Pressure

Trial Design

2Treatment groups
Experimental Treatment
Group I: Minimal to No Respiratory WeaknessExperimental Treatment1 Intervention
MIP ≥ 70% predicted Complete home-based RMT program and participate in weekly web-based RMT therapy sessions.
Group II: Mild to Moderate Inspiratory WeaknessExperimental Treatment1 Intervention
MIP 40-70% predicted Complete home-based RMT program and participate in weekly web-based RMT therapy sessions.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Respiratory Muscle Training
2013
N/A
~140

Find a Location

Who is running the clinical trial?

Duke UniversityLead Sponsor
2,363 Previous Clinical Trials
3,420,477 Total Patients Enrolled
Harrison Jones, PhDPrincipal InvestigatorDuke University
4 Previous Clinical Trials
135 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Respiratory Muscle Training (RMT) in ALS
2020. "Respiratory Muscle Training (RMT) in ALS". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04224961.
~2 spots leftby Apr 2025
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