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Artificial Sweetener

Group 1- Healthy Lean subjects for Obesity (ISTAR-micro Trial)

N/A
Waitlist Available
Led By Richard Pratley, MD
Research Sponsored by Translational Research Institute for Metabolism and Diabetes, Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks
Awards & highlights

ISTAR-micro Trial Summary

This trial will study the effects of short-term consumption of artificial sweeteners on blood sugar levels and gut bacteria.

ISTAR-micro Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Blood analyzed by way of NOVA StatStrip Meter and Milliplex Map Kit.
Secondary outcome measures
Short chain fatty acid analyses

ISTAR-micro Trial Design

4Treatment groups
Active Control
Group I: Group 1- Healthy Lean subjectsActive Control4 Interventions
Group 1 will receive Sodium Saccharin 200mg capsule, 2x/day, Day 1-14
Group II: Group 2- Healthy Lean subjectsActive Control4 Interventions
Group 2 will receive Placebo 500mg capsule, 2x/day, Day 1-14
Group III: Group 3- Healthy Lean subjectsActive Control5 Interventions
Group 3 will receive Sodium Saccharin 200mg + lactisole 335mg capsule, 2x/day, Day 1-14
Group IV: Group 4- Healthy Lean subjectsActive Control4 Interventions
Group 4 will receive Lactisole 335mg capsule, 2x/day, Day 1-14

Find a Location

Who is running the clinical trial?

Translational Research Institute for Metabolism and Diabetes, FloridaLead Sponsor
40 Previous Clinical Trials
3,495 Total Patients Enrolled
11 Trials studying Obesity
267 Patients Enrolled for Obesity
AdventHealth Translational Research InstituteLead Sponsor
48 Previous Clinical Trials
20,079 Total Patients Enrolled
11 Trials studying Obesity
267 Patients Enrolled for Obesity
Richard Pratley, MDPrincipal InvestigatorTranslational Research Institute for Metabolism and Diabetes
9 Previous Clinical Trials
867 Total Patients Enrolled
1 Trials studying Obesity
32 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
XenobioticaJournal
The Metabolism of Intense Sweeteners
Renwick, A. G.. 1986. “The Metabolism of Intense Sweeteners”. Xenobiotica. Informa UK Limited. doi:10.3109/00498258609038983.
Food and Chemical ToxicologyJournal
The Disposition of Saccharin in Animals and Man—a Review
Renwick, A.G.. 1985. “The Disposition of Saccharin in Animals and Man—a Review”. Food and Chemical Toxicology. Elsevier BV. doi:10.1016/0278-6915(85)90136-x.
HeliyonJournal
Pollution Status, Health Risk Assessment of Potentially Toxic Elements in Soil and Their Uptake by Gongronema Latifolium in Peri-urban of Ora-eri, South-eastern Nigeria
Mmaduakor, Ebuka Chidiebere, Chisom Theresa Umeh, Joy Ebele Morah, Daniel Omeodisemi Omokpariola, Azubuike Amos Ekwuofu, and Somto Stephen Onwuegbuokwu. 2022. “Pollution Status, Health Risk Assessment of Potentially Toxic Elements in Soil and Their Uptake by Gongronema Latifolium in Peri-urban of Ora-eri, South-eastern Nigeria”. Heliyon. Elsevier BV. doi:10.1016/j.heliyon.2022.e10362.
Journal of Clinical InvestigationJournal
Gut Microbiome, Obesity, and Metabolic Dysfunction
Tilg, Herbert, and Arthur Kaser. 2011. “Gut Microbiome, Obesity, and Metabolic Dysfunction”. Journal of Clinical Investigation. American Society for Clinical Investigation. doi:10.1172/jci58109.
~12 spots leftby Apr 2025
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