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Antibiotic

Azithromycin for Microbiome

N/A
Waitlist Available
Led By Jennie H. Kwon, DO, MSCI
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy adults ages 21-60 residing in the St. Louis, Missouri, USA metropolitan area
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up decrease from baseline (7 days prior to antibiotics) in microbial diversity at 185 days post-antibiotics
Awards & highlights

Study Summary

This trial will study the effect of antibiotics on the microbiome of healthy adults.

Eligible Conditions
  • Microbiome
  • Antibiotics

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~decrease from baseline (7 days prior to antibiotics) in microbial diversity at 185 days post-antibiotics
This trial's timeline: 3 weeks for screening, Varies for treatment, and decrease from baseline (7 days prior to antibiotics) in microbial diversity at 185 days post-antibiotics for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Superinfection
Multidrug Resistance Gene
Superinfection

Trial Design

4Treatment groups
Experimental Treatment
Group I: LevofloxacinExperimental Treatment1 Intervention
1 750mg tab of levofloxacin by mouth for 5 days
Group II: CefpodoximeExperimental Treatment1 Intervention
200mg tab by mouth twice per day for 5 days
Group III: Azithromycin and cefpodoximeExperimental Treatment2 Interventions
Azithromycin: 1 500mg tab by mouth on day 1, then 1 250 mg tab per day by mouth for 4 days (total 5 days) Cefpodoxime: 200mg tab by mouth twice per day for 5 days
Group IV: AzithromycinExperimental Treatment1 Intervention
1 500mg tab by mouth on day 1, then 1 250 mg tab per day by mouth for 4 days (total 5 days)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Levofloxacin
2011
Completed Phase 4
~8180
Azithromycin
2018
Completed Phase 4
~274950
Cefpodoxime
2017
N/A
~320

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,935 Previous Clinical Trials
2,299,787 Total Patients Enrolled
Jennie H. Kwon, DO, MSCIPrincipal InvestigatorWashington University School of Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Healthy Patients & Effect of Antibiotics
2017. "Healthy Patients & Effect of Antibiotics". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03098485.
~2 spots leftby Apr 2025
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