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Auditory Startle Device for Healthy Subjects

N/A
Waitlist Available
Led By Christian Grillon, Ph.D.
Research Sponsored by National Institute of Mental Health (NIMH)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 250 ms at a rate of one every 2000 ms
Awards & highlights

Study Summary

This trial will help researchers understand how personality and past experiences affect people's reactions to fear and other unpleasant stimuli.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~250 ms at a rate of one every 2000 ms
This trial's timeline: 3 weeks for screening, Varies for treatment, and 250 ms at a rate of one every 2000 ms for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Correct-go Reaction Time (RT)
Go Correct Hits Followed by Button Press
Nogo Trials Followed by no Button Press
+2 more
Secondary outcome measures
Measure of Attention Control
Measure of Level of Anxiety

Trial Design

1Treatment groups
Experimental Treatment
Group I: Healthy volunteersExperimental Treatment2 Interventions
Sub-study A: Working memory task / Participant performed a working memory task in two conditions, under threat of shock and in safety and asked to remember verbal and nonverbal stimuli from the current stimulus on the screen (N-back task) Sub-study C: Sustained attention to response task (SART) / participant was presented with stimuli and either initiated a response (i.e. "go") or inhibited their response (i.e. "stop") based on what stimuli were presented Sub-study D: Stroop task/ In the classic Stroop test, the name of a color is printed in a color that conflicts or does not conflict with the word. In the emotional Stroop, the words emotional words. The participant's task was to name the color of the word Pilot studies / (1) Shocks were delivered via electrodes located on the forearm or fingers while participant performed a working memory or vigilance task or (2) Subject performed cognitive tasks during alternating safe and threat periods
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Shock Device
2001
N/A
~1420
Auditory Startle Device
2001
N/A
~1420

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)Lead Sponsor
2,785 Previous Clinical Trials
2,688,338 Total Patients Enrolled
Christian Grillon, Ph.D.Principal InvestigatorNational Institute of Mental Health (NIMH)
6 Previous Clinical Trials
2,421 Total Patients Enrolled
Monique Ernst, M.D.Principal InvestigatorNational Institute of Mental Health (NIMH)
10 Previous Clinical Trials
7,970 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effects of Arousal and Stress in Anxiety
2001. "Effects of Arousal and Stress in Anxiety". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00026559.
~58 spots leftby Apr 2025
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