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Monoclonal Antibodies

AGEN1884 + AGEN2034 for Cervical Cancer

Phase 1 & 2
Waitlist Available
Research Sponsored by Agenus Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up duration of the trial, up to 3 years.
Awards & highlights

Study Summary

This trial is testing a new combination cancer treatment of two drugs, AGEN1884 and AGEN2034, in people with locally advanced, recurrent, or metastatic solid tumors.

Eligible Conditions
  • Cervical Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~duration of the trial, up to 3 years.
This trial's timeline: 3 weeks for screening, Varies for treatment, and duration of the trial, up to 3 years. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Objective Response Rate (ORR), as determined by IERC, in the analysis population
Secondary outcome measures
Area under the drug concentration-time curve from time zero to time t (AUC(0-t)), area under the drug concentration-time curve from time zero to infinity (AUC(0-∞))
Area under the drug concentration-time curve within time span t1 to t2 at steady-state (AUC(τ1-τ2)-ss)
Disease Control Rate (DCR)
+15 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: AGEN1884 + AGEN2034Experimental Treatment1 Intervention
AGEN1884 in combination with AGEN2034 in subjects with Subjects with Metastatic or Locally Advanced Solid Tumors, and Expansion into Select Solid Tumors (cervical)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
AGEN1884 + AGEN2034
2017
Completed Phase 2
~160

Find a Location

Who is running the clinical trial?

Agenus Inc.Lead Sponsor
51 Previous Clinical Trials
4,581 Total Patients Enrolled
Medical DirectorStudy DirectorAgenus Inc.
2,777 Previous Clinical Trials
8,064,065 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Subjects With Metastatic or Locally Advanced Solid Tumors, and Expansion Into Select Solid Tumors (Cervical)
2017. "Subjects With Metastatic or Locally Advanced Solid Tumors, and Expansion Into Select Solid Tumors (Cervical)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03495882.
~21 spots leftby Apr 2025
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