Coenzyme Q10 for Chronic Fatigue Syndrome
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines whether a supplement called coenzyme Q10 can help individuals experiencing chronic fatigue symptoms after the February 2023 train derailment in East Palestine, Ohio. Participants will receive either the coenzyme Q10 supplement or a placebo (a pill with no active ingredient) to compare effects. The trial aims to determine if this supplement can improve quality of life and physical function for those affected. Individuals who lived within 10 miles of the derailment and have experienced new or worsened fatigue, pain, or other symptoms since then might be suitable candidates. Participants need internet access and must be willing to follow study instructions. As a Phase 2 trial, this research focuses on measuring the treatment's effectiveness in an initial, smaller group of people.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using coumadin due to potential interactions with CoQ10.
Is there any evidence suggesting that coenzyme Q10 is likely to be safe for humans?
Research has shown that Coenzyme Q10 (CoQ10) is generally safe as a dietary supplement. Studies suggest that taking up to 1,200 mg per day is unlikely to cause harm, though most people take a lower dose, usually between 100 to 200 mg daily. In this trial, participants will take 100 mg three times a day. Other studies have used CoQ10 to help manage symptoms of chronic fatigue syndrome, with no serious side effects reported.
Although specific safety data from this study is not yet available, CoQ10 is already known to be well-tolerated in humans. For those considering joining the trial, the safety of CoQ10 appears promising based on past research.12345Why do researchers think this study treatment might be promising for chronic fatigue syndrome?
Unlike the standard treatments for Chronic Fatigue Syndrome, which often involve medications like antidepressants, cognitive behavioral therapy, or graded exercise therapy, Coenzyme Q10 (CoQ10) offers a unique approach. CoQ10 is a naturally occurring antioxidant that plays a vital role in energy production within cells. Researchers are excited about CoQ10 because it targets mitochondrial function, potentially addressing the root cause of energy depletion in Chronic Fatigue Syndrome. Additionally, since CoQ10 is taken as a supplement, it may offer a more natural and potentially safer alternative to conventional medications.
What evidence suggests that Coenzyme Q10 might be an effective treatment for chronic fatigue syndrome?
Studies have shown that Coenzyme Q10 (CoQ10) can help reduce feelings of tiredness. This trial will provide participants with either CoQ10 or a placebo to explore its potential as a treatment for chronic fatigue syndrome (CFS), which includes symptoms like tiredness, pain, and sleep problems. Research suggests that CoQ10, especially when combined with other nutrients like selenium, might improve the quality of life for people with CFS. Some studies indicate that CoQ10 can increase energy and enhance physical activity. Overall, the evidence supports CoQ10's potential as an effective option for easing fatigue and related symptoms.678910
Who Is on the Research Team?
Beatrice A. Golomb, MD, PhD
Principal Investigator
University of California, San Diego
Are You a Good Fit for This Trial?
This trial is for individuals with Chronic Fatigue Syndrome potentially linked to the East Palestine, Ohio train derailment in February 2023. It's a pilot study to see if Coenzyme Q10 can help improve their quality of life and physical function.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment Phase 1
Participants receive CoQ10 or placebo for the first treatment phase
Crossover Treatment Phase 2
Participants switch treatments (CoQ10 or placebo) for the second phase
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Coenzyme Q10
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Diego
Lead Sponsor