CBD + THC for HIV/AIDS
(CAMI Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study has the potential to contribute to a more complete understanding of the independent and combined effects of cannabis use and HIV on the brain and on inflammation. Such knowledge may inform future strategies for treating brain disease and inflammation. Participants will be randomly assigned to one of two groups, both of which will receive the same treatment in a different order over a period of about 6 weeks. The visits include physical examinations, blood tests, and other procedures designed to monitor subject safety and measure the effects of the study drug.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it excludes those using medications with significant interactions or sedating effects. It's best to discuss your specific medications with the trial team.
How does the drug CBD + THC for HIV/AIDS differ from other treatments?
Who Is on the Research Team?
Ronald J Ellis, MD, PhD
Principal Investigator
UC San Diego
Are You a Good Fit for This Trial?
This trial is for adults aged 21-60 who have used THC-containing cannabis at least once in the past 5 years without severe side effects and have low or no cannabis use recently. HIV-positive participants must be virally suppressed, on stable ART with a 'normal' CD4 count, and able to follow the study schedule. Exclusions include significant cognitive impairment, compromised liver/kidney function, allergies to study drugs, heavy substance use (except cannabis), pregnancy/lactation without contraception, certain chronic diseases like diabetes requiring insulin or uncontrolled psychiatric disorders.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomly assigned to receive either THC or CBD for 2 weeks, followed by a 2-week washout period, and then the alternate treatment for another 2 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- CBD
- THC
CBD is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Diego
Lead Sponsor