Topical Timolol for Mohs Surgery Wounds

Overseen By Amrit Greene, MD

Age: 18+

Sex: Any

Trial Phase: Phase 2

Sponsor: Geisinger Clinic

Must not be taking: Opioids, Benzodiazepines

Disqualifiers: Asthma, COPD, Heart failure, others

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 7

Duration: 12 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this study clinical trial is to learn if topical timolol can accelerate healing and improve the cosmetic appearance of surgical wounds on the scalp following Mohs surgery. It will include Geisinger patients 18 year or older who undergo Mohs surgery of the scalp with planned wound healing by secondary intent. The main questions in aim to answer are:

1. Compare wound healing speed between patients treated with topical timolol and those receiving standard wound care only.

2. Compare cosmetic outcomes using topical timolol and standard wound care.

3. Evaluate the impact of topical timolol on the number of unplanned follow-up visits and calls related to delayed wound healing.

Participants will be asked use either topical timolol or use standard wound care to treat their Mohs surgery scalp wound. They will follow-up around 4, 8 and 12 weeks.

Who Is on the Research Team?

Amrit Greene, MD

Principal Investigator

Geisinger Clinic

Are You a Good Fit for This Trial?

This trial is for adults (18 or older) who have had Mohs surgery on their scalp and will let the wound heal naturally. Participants must be Geisinger patients. People with other health issues affecting healing may not qualify.

Inclusion Criteria

Ability to provide informed consent

Willingness to comply with study procedures and attend follow-up visits

I am 18 or older and have had Mohs surgery on my scalp.

Exclusion Criteria

I am allergic or sensitive to timolol or ingredients in the study drug.

Bronchial asthma or history of bronchial asthma

Sinus bradycardia

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either topical timolol or standard wound care for their Mohs surgery scalp wound

12 weeks

Follow-up visits at 4, 8, and 12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment, including wound healing and cosmetic outcomes

12 weeks

3 visits (in-person) at 4, 8, and 12 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Topical Timolol

Trial Overview

The study compares two treatments for scalp wounds after Mohs surgery: applying topical timolol versus using standard wound care (normal saline). Patients are assigned to one of these groups to see which helps wounds heal faster and look better.

How Is the Trial Designed?

Group I: Timolol Arm Active Control 1 Intervention

This arm will have their wounds treated with topical timolol.

Group II: Standard of Care Arm Placebo Group 1 Intervention

This arm will have their wounds treated with normal saline/standard of care.

Who Is Running the Clinical Trial?

Geisinger Clinic

Lead Sponsor

Trials

159

Recruited

1,976,000+