This trial is evaluating whether DKN-01 600 mg will improve 4 primary outcomes in patients with Prostate Cancer. Measurement will happen over the course of Baseline to End of Cycle 1 (each cycle is 28 days).
This trial requires 97 total participants across 5 different treatment groups
This trial involves 5 different treatments. DKN-01 600 Mg is the primary treatment being studied. Participants will be divided into 5 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
Prostate cancer is a disease in which cells that are mutated or abnormal grow in the prostate gland and invade nearby structures leading to symptoms of enlargement of the testicles and difficulty passing urine and other symptoms. PSA tests are used to help diagnose prostate cancer and determine if treatment is needed. Although there are benefits to screening for prostate cancer, the current evidence does not support the effectiveness of screening, or of PSA tests in particular.
The signs of prostate cancer include recurrent fever, painful or painful erections or weakness in the legs. Some signs of prostate cancer also include feeling depressed or suicidal, having trouble with bladder control, urinary frequency or urgency, frequent urination or an unexplained lump and soreness in the groin. In many men, prostate cancer also causes unexplained changes in the frequency, urgency and flow of urination.\n
Around 250,000 cases of [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer) are diagnosed each year in the United States, making it the most common cancer in American men. The American College of Physicians published its second edition of the Choosing Wisely campaign for prostate cancer in May 2018. That July, the American Urological Association published its first prostate cancer guideline on the use of screening, which encourages screening for men who are 60 years and older, are of African American or Hispanic descent, or have a relatively young age of onset (< 50 years).
The relationship between physical activity and prostate cancer is complex, with the possible role of different strains of physical exercise being debated. The impact of aerobic exercise on prostate cancer seems to arise in later life, while strength exercise is inversely associated. The role of lifestyle in prostate cancer risk should be investigated further.
The concept of cure as described by the Mayo Clinic does not apply to [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer). Furthermore, early detection of cancer by digital rectal examination combined with radical prostatectomy appears to have a positive impact on health-related quality of life.
Treating prostate cancer is also based on the initial treatment of the disease. This could be by watchful waiting, active surveillance or chemotherapy. There are numerous types of therapy used but androgen receptor-targeting agents play a large role in prostate cancer treatment.
The two major genetic factors leading to prostate cancer are inheritance factors and environmental factors. The primary cause of prostate cancer is inherited, though external environmental risk factors may play a role later in one's life, like exposure to certain chemical carcinogens while working in factories or on farms or the fact that a person with a family history of prostate cancer may have inherited a 'high risk' gene mutation. At this time, the primary cause of prostate cancer is inherited. The primary cause of prostate cancer is inherited, though both shared environmental and non-shared environmental factors seem to play a role later in one's life.
The present trial demonstrated a significant decrease in PSA from baseline to week 6 in all patient groups, with no statistically significant differences in prostate cancer.
Men with [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer) usually present with metastasis from the prostate at an average age of 61 years. The average age of the men with prostate cancer who died from prostate cancer was 69 years, and the patients diagnosed with prostate cancer before age 40 years had a 5-year and 10-year survival rates of 61% and 60%, respectively. Prostate cancer continues to be a disease of the elderly.
There is a higher overall risk of PCa in relatives of cases than of controls and this is greatest for high-grade PCa (HR = 1.76, 95% CI = 1.06-2.94). Associations may also be detectable for high-grade PCa among first-degree and second-degree relatives.
Results from a recent clinical trial, both 600 mg and 600 mg with other DDSs were effective in the treatment of CCRSTM. Further studies are required on a larger number of patients to confirm the high rate of remission.
dkn-01 (600 mg) has a significant anti-malarial activity and exhibits good pharmacokinetic profile. Both of these properties should help prevent the development of resistant strains. dkn-01 is more effective as compared with dkn-02, which showed only a modest antiprotozoal activity. The combination of both dkn-01 with clindamycin is as efficient as dkn-01 alone in eradicating experimental Trypazolam-resistant "T.