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Anti-mitotic Agent
Docetaxel + Estramustine for Prostate Cancer
Phase 1 & 2
Waitlist Available
Research Sponsored by Herbert Irving Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Hepatic: Bilirubin no greater than upper limit of normal (ULN), SGOT or SGPT no greater than 2.0 times ULN, Alkaline phosphatase no greater than 5.0 times ULN
Neurologic: No prior cerebrovascular accident, No symptomatic peripheral neuropathy greater than grade 1, No significant neurologic or psychiatric disorder (psychotic disorder, dementia, or seizure)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying combining docetaxel and estramustine to see how well they work in treating patients with metastatic prostate cancer.
Who is the study for?
This trial is for adults with metastatic prostate cancer who have not responded to hormone therapy. They should not have brain involvement, recent heart attacks, or severe fluid buildup. Participants need a stable blood count and organ function, no serious infections or other cancers in the last 5 years (except certain skin cancers), and must be at least 4 weeks out from previous treatments.Check my eligibility
What is being tested?
The study is testing the combination of two chemotherapy drugs, docetaxel and estramustine, to see how effective they are together in treating metastatic prostate cancer. It's a Phase I/II trial which means it's looking at both safety and effectiveness.See study design
What are the potential side effects?
Possible side effects include reactions related to infusion of the drugs, increased risk of infection due to lowered white blood cell counts, fatigue, digestive issues like nausea or diarrhea, potential bleeding problems due to low platelets, liver function changes indicated by blood tests.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My liver function tests are within normal limits.
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I haven't had a stroke, severe nerve damage, or major brain/mental health issues.
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My prostate cancer did not respond to hormone therapy.
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My creatinine levels are not more than twice the upper limit of normal.
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I am 18 years old or older.
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I do not have any current infections.
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My prostate cancer has spread and was confirmed by a biopsy.
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I don't have severe swelling or fluid build-up in my body.
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My cancer has not spread to my brain or its coverings.
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I am able to get out of my bed or chair and move around.
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My cancer can be measured or seen on tests.
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I do not have any serious illnesses besides my current condition.
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I have never had a blood clot in my lungs.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Find a Location
Who is running the clinical trial?
Herbert Irving Comprehensive Cancer CenterLead Sponsor
33 Previous Clinical Trials
892 Total Patients Enrolled
2 Trials studying Prostate Cancer
117 Patients Enrolled for Prostate Cancer
Daniel P. Petrylak, MDStudy ChairHerbert Irving Comprehensive Cancer Center
5 Previous Clinical Trials
1,209 Total Patients Enrolled
3 Trials studying Prostate Cancer
1,172 Patients Enrolled for Prostate Cancer
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I haven't had any cancer except for non-melanoma skin cancer treated successfully in the past 5 years.My liver function tests are within normal limits.I haven't had a stroke, severe nerve damage, or major brain/mental health issues.I have not had a heart attack in the last 6 months.My prostate cancer did not respond to hormone therapy.It has been over 4 weeks since my last hormonal therapy.My creatinine levels are not more than twice the upper limit of normal.I haven't had radiation on more than 30% of my bone marrow.I am 18 years old or older.I do not have any current infections.My prostate cancer has spread and was confirmed by a biopsy.I don't have severe swelling or fluid build-up in my body.My cancer has not spread to my brain or its coverings.I am able to get out of my bed or chair and move around.It has been over 4 weeks since my last radiation treatment.It has been over 4 weeks since my last chemotherapy session.My cancer can be measured or seen on tests.I do not have any serious illnesses besides my current condition.It has been over 6 weeks since my last isotope therapy.I have never had a blood clot in my lungs.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this research endeavor still recruiting participants?
"According to clinicaltrials.gov, this medical trial has ended its recruitment phase, having first opened on February 1st 1998 and had the details last updated January 3rd 2014. Nevertheless, there are over 1300 other trials recruiting patients at present."
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