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Androgen

DHEA+Testosterone for Primary Ovarian Insufficiency

Q: What is the typical purpose for taking a combination of DHEA and Testosterone?

<p>DHEA+<a href="https://www.withpower.com/clinical-trials/testosterone">Testosterone</a> is often administered to patients with hypogonadotropic hypogonadism. It has been found to be a successful treatment for numerous other conditions such as 1-5 years postmenopausal symptoms, orchidectomy, and orchitis.</p>

Phase 1 & 2

Waitlist Available

Led By David H Barad, MD, MS

Research Sponsored by Center for Human Reproduction

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 8 weeks post treatment initiation

Awards & highlights

Study Summary

This trial will compare the effects of testosterone cream to placebo on measures of ovarian reserve, oocyte quality, embryo quality, and pregnancy rates in women with diminished ovarian reserve who have low serum testosterone and free testosterone levels after completing six weeks of DHEA supplementation.

Eligible Conditions

Primary Ovarian Insufficiency
Female Infertility

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 8 weeks post treatment initiation

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~8 weeks post treatment initiation

This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks post treatment initiation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Clinical and Ongoing Pregnancy

Secondary outcome measures

Measures of Atresia

Oocytes number

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: DHEA+TestosteroneActive Control2 Interventions

These patients will be administered the testosterone cream along with standard DHEA supplements

Group II: DHEA+PlaceboPlacebo Group2 Interventions

These patients will receive the placebo cream along with her DHEA supplements. In other words, no testosterone will be administered.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Center for Human ReproductionLead Sponsor

13 Previous Clinical Trials

987 Total Patients Enrolled

2 Trials studying Primary Ovarian Insufficiency

69 Patients Enrolled for Primary Ovarian Insufficiency

Foundation for Reproductive MedicineOTHER

3 Previous Clinical Trials

149 Total Patients Enrolled

Norbert Gleicher, MDStudy ChairCenter for Human Reproduction

8 Previous Clinical Trials

645 Total Patients Enrolled

3 Trials studying Primary Ovarian Insufficiency

74 Patients Enrolled for Primary Ovarian Insufficiency

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the typical purpose for taking a combination of DHEA and Testosterone?

"DHEA+Testosterone is often administered to patients with hypogonadotropic hypogonadism. It has been found to be a successful treatment for numerous other conditions such as 1-5 years postmenopausal symptoms, orchidectomy, and orchitis."

Answered by AI

Is the research team still seeking participants for this experiment?

"The details on clinicaltrials.gov indicate that this trial is currently enrolling volunteers; the research project was first posted to the database on July 1st 2012 and has undergone changes as recently as November 9th 2020."

Answered by AI

How many volunteers have been recruited to participate in this experiment?

"Affirmative. Clinicaltrials.gov data reveals that this clinical trial, which appeared on July 1st 2012, is currently searching for participants. This research necessitates 180 patients from one centre to be enrolled."

Answered by AI

Is there an age limit for participation in this research endeavor?

"This study is searching for individuals between 38 and 44 years old to partake in its medical trial."

Answered by AI

Are there any precedented studies involving the combined use of DHEA and testosterone?

"At the moment, there are 29 ongoing medical trials investigating DHEA+Testosterone with 5 of those in their final stages. Of these studies, 124 are conducted at various locations across the United States including Houston, Texas."

Answered by AI

Who is eligible to participate in this investigation?

"Candidates wanting to participate in this research must have primary ovarian insufficiency and fall between the ages of 38-44. The overall recruitment goal is 180 individuals."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effect of Testosterone Treatment on Embryo Quality

2012. "Effect of Testosterone Treatment on Embryo Quality". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01662466.

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