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Lipase Inhibitor

Orlistat for Polybrominated Biphenyl Poisoning

Phase 4
Waitlist Available
Led By Michele Marcus, PhD/MPH
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up screening, 3 and 6 months follow up visits
Awards & highlights

Study Summary

This study is evaluating whether a drug used to help with weight loss may also help reduce the body burden of certain chemicals.

Eligible Conditions
  • Polybrominated Biphenyl Poisoning

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~screening, 3 and 6 months follow up visits
This trial's timeline: 3 weeks for screening, Varies for treatment, and screening, 3 and 6 months follow up visits for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Body Mass Index
Change in weight
Secondary outcome measures
Change in dietary intake using Automated Self-administered 24-hour Recall score
Change in physical activity
Change in serum concentration of PCB 138
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Orlistat Weight Loss AidExperimental Treatment2 Interventions
Participants randomized to take orlistat at the over-the-counter dose for six months. Diet and exercise plus a daily multivitamin will also be recommended and monitored.
Group II: PlaceboPlacebo Group2 Interventions
Participants randomized to take a placebo to match orlistat at the over-the-counter dose for six months. Diet and exercise plus a daily multivitamin will also be recommended and monitored.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Multivitamin
2016
Completed Phase 4
~20750
Orlistat
2022
Completed Phase 4
~1490

Find a Location

Who is running the clinical trial?

National Institute of Environmental Health Sciences (NIEHS)NIH
283 Previous Clinical Trials
1,232,137 Total Patients Enrolled
Michigan Public Health DepartmentsUNKNOWN
Emory UniversityLead Sponsor
1,636 Previous Clinical Trials
2,560,530 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Weight Loss Aid in an Exposed Population
Michele Marcus 2018. "Weight Loss Aid in an Exposed Population". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03582722.
~15 spots leftby Apr 2025
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