All > Acute Pain > Pain

Methylphenidate for Pain

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Northwestern University, Chicago, ILPainMethylphenidate - Drug
Eligibility
18 - 65
All Sexes
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Study Summary

This trial will investigate how dopamine affects the disconnect between pain caused by a stimulus and the pain felt, with the aim of understanding chronic pain better.

Eligible Conditions
  • Pain

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

1
Mavoglurant (AFQ056)
1
Methylphenidate
1
Pramipexole

Study Objectives

4 Primary · 0 Secondary · Reporting Duration: 6 months

6 months
Effect of methylphenidate on acute pain dynamics
Effect of methylphenidate on offset analgesia
Nucleus accumbens activation with acute pain dynamics
Nucleus accumbens dynamics during offset analgesia

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Similar Trials

1
Mavoglurant (AFQ056)
1
Methylphenidate
1
Pramipexole

Side Effects for

Phase 1-Medication First
51%Appetite Loss
40%Insomnia
33%Irritability
29%Picking at skin, nailbiting
21%Dull, tired, listless
21%Worried/Anxious
19%Tearful, depressed
18%Stomachache
13%Motor Tics
13%Headache
12%Buccal-lingual movements
10%Social Withdrawal
1%Hospitalized
This histogram enumerates side effects from a completed 2020 Phase 4 trial (NCT02039908) in the Phase 1-Medication First ARM group. Side effects include: Appetite Loss with 51%, Insomnia with 40%, Irritability with 33%, Picking at skin, nailbiting with 29%, Dull, tired, listless with 21%.

Trial Design

2 Treatment Groups

Methylphenidate
1 of 2
Placebo
1 of 2

Experimental Treatment

Non-Treatment Group

30 Total Participants · 2 Treatment Groups

Primary Treatment: Methylphenidate · Has Placebo Group · Phase 2

Methylphenidate
Drug
Experimental Group · 1 Intervention: Methylphenidate · Intervention Types: Drug
Placebo
Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Methylphenidate
2014
Completed Phase 4
~432010

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 6 months

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,477 Previous Clinical Trials
811,027 Total Patients Enrolled
45 Trials studying Pain
3,839 Patients Enrolled for Pain
National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,270 Previous Clinical Trials
456,072 Total Patients Enrolled
16 Trials studying Pain
3,511 Patients Enrolled for Pain
Andrew D Vigotsky, MSPrincipal InvestigatorNorthwestern University

Eligibility Criteria

Age 18 - 65 · All Participants · 0 Total Inclusion Criteria

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References

Frequently Asked Questions

Does this medical experiment accept enrollees aged 45 and up?

"This clinical study is in search of participants that are over 18 years old and below 65." - Anonymous Online Contributor

Unverified Answer

Who meets the specified criteria to participate in this clinical experiment?

"To qualify for this research project, applicants must experience pain and be between 18 to 65 years of age. The team is aiming to recruit around 30 participants in total." - Anonymous Online Contributor

Unverified Answer

Has the Federal Drug Administration approved Methylphenidate for use?

"Our team at Power assigned Methylphenidate a safety score of 2, as this is a Phase 2 trial and while there are some data points attesting to its safety, none have yet been collected which support its efficacy." - Anonymous Online Contributor

Unverified Answer

Is recruitment for this trial still open?

"Clinicaltrials.gov records assert that this medical investigation is in search of participants, with the original post being made on September 19th 2022 and updated most recently on December 30th 2022." - Anonymous Online Contributor

Unverified Answer

How many individuals are being studied as part of this medical investigation?

"Affirmative, the info hosted on clinicaltrials.gov shows that this medical study is actively looking for subjects to join. This trial was first published on September 19th 2022 and has been latest revised at December 30th of the same year. The researchers are aiming to enrol a total of thirty individuals across one location." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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