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Vasodilator

Oral Minoxidil for Platinum-Resistant Ovarian Cancer

Phase 2
Recruiting
Led By Margaret Liotta, DO
Research Sponsored by Loyola University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participants must have platinum resistant disease defined as recurrence less than 6 months after initial platinum based treatment.
Participants must have an Eastern Cooperative Group (ECOG) Performance Status (PS) less than or equal to 2.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 24 months
Awards & highlights

Study Summary

This trial is testing oral minoxidil for ovarian cancer that has come back and is resistant to platinum drugs. The goal is to see if it works and if so, how well and with what side effects.

Who is the study for?
This trial is for adults over 18 with recurrent platinum-resistant ovarian cancer, who can take pills and have an ECOG Performance Status of 2 or less. They must not have had chemo or radiotherapy in the last 4 weeks, be on other trials, have heart failure or disease, be on dialysis, have brain metastases, allergies to minoxidil, or uncontrolled high blood pressure.Check my eligibility
What is being tested?
The study tests if oral Minoxidil helps patients with recurrent platinum-resistant ovarian cancer. It looks at how many respond to treatment, time before the disease gets worse again and records any side effects. It also explores whether a genetic factor (Kir6/SUR complex) affects Minoxidil's effectiveness.See study design
What are the potential side effects?
Minoxidil may cause side effects such as fluid retention leading to rapid weight gain; swelling of face, hands, ankles; difficulty breathing; fast heartbeat; nausea; vomiting; breast pain/tenderness; changes in hair growth/loss.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My cancer came back within 6 months after platinum-based treatment.
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I can take care of myself and am up and about more than half of my waking hours.
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I am 18 years old or older.
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I can take medicine by mouth.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Overall response rate (ORR)
Secondary outcome measures
Progression-free survival (PFS)

Side effects data

From 2015 Phase 2 trial • 21 Patients • NCT00876200
56%
Hypertrichosis
11%
Strabismus correction
100%
80%
60%
40%
20%
0%
Study treatment Arm
Minoxidil
Placebo

Trial Design

1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment1 Intervention
Participants in this arm will be treated with minoxidil. This treatment will be given daily by mouth.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Minoxidil
2011
Completed Phase 2
~170

Find a Location

Who is running the clinical trial?

Loyola UniversityLead Sponsor
156 Previous Clinical Trials
30,900 Total Patients Enrolled
4 Trials studying Ovarian Cancer
76 Patients Enrolled for Ovarian Cancer
Cures Within ReachOTHER
19 Previous Clinical Trials
1,709 Total Patients Enrolled
Medical University of South CarolinaOTHER
933 Previous Clinical Trials
7,394,581 Total Patients Enrolled
1 Trials studying Ovarian Cancer
150 Patients Enrolled for Ovarian Cancer

Media Library

Minoxidil (Vasodilator) Clinical Trial Eligibility Overview. Trial Name: NCT05272462 — Phase 2
Ovarian Cancer Research Study Groups: Treatment
Ovarian Cancer Clinical Trial 2023: Minoxidil Highlights & Side Effects. Trial Name: NCT05272462 — Phase 2
Minoxidil (Vasodilator) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05272462 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are taking part in this clinical trial?

"That is correct, the online information states that the trial is looking for more participants. The listing was first posted on December 13th 2021 and was updated as recently as June 23rd 2022. So far, 34 people have been enrolled at 1 site."

Answered by AI

Which patients are qualified to take part in this research?

"This study is for women who have ovarian cancer and are between 18-90 years old. Up to 34 patients will be enrolled in the trial."

Answered by AI

Are recruitment efforts for this research still underway?

"Yes, this clinical study is still recruiting patients. It was originally posted on December 13th 2021 and the listing was updated on June 23rd of this year."

Answered by AI

What are the risks associated with using Minoxidil?

"Minoxidil received a score of 2 because Phase 2 trials have not shown evidence of efficacy, only safety."

Answered by AI

Is this trial open to people who are over the age of 20 years old?

"The age requisites for potential participants in this trial are that they must have turned 18 years old and cannot be older than 90 years old."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Oral Minoxidil for the Treatment of Recurrent Platinum Resistant Epithelial Ovarian Cancer
Margaret Liotta 2021. "Oral Minoxidil for the Treatment of Recurrent Platinum Resistant Epithelial Ovarian Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05272462.
~8 spots leftby Dec 2024
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