Oral Minoxidil for Platinum-Resistant Ovarian Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to evaluate the effectiveness of oral minoxidil for individuals with platinum-resistant ovarian cancer that has recurred after treatment. Researchers seek to determine the time it takes for the cancer to progress during this treatment and to identify any side effects. The study seeks participants whose ovarian cancer recurred less than six months after completing initial treatment with platinum-based drugs and who can take oral medications. As a Phase 2 trial, this research focuses on assessing the treatment's effectiveness in an initial, smaller group of participants.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot be on any other investigational agents or have had chemotherapy or radiotherapy within 4 weeks.
Is there any evidence suggesting that oral minoxidil is likely to be safe for humans?
Research shows that oral minoxidil, originally used for high blood pressure, is under study for its potential to treat ovarian cancer unresponsive to standard treatments. Since minoxidil is already approved for other uses, researchers have some confidence in its safety. People using minoxidil for other conditions generally tolerate it well. However, like any medication, it can cause side effects. Common side effects include changes in blood pressure and heart rate, so monitoring these during treatment is important. While more detailed safety information specific to its use in ovarian cancer is still being collected, the ongoing study aims to identify any unique concerns. Participants should stay informed and regularly consult their healthcare providers throughout the trial.12345
Why do researchers think this study treatment might be promising for ovarian cancer?
Unlike the standard treatments for platinum-resistant ovarian cancer, which typically involve chemotherapy drugs like paclitaxel, oral minoxidil is being studied for its unique approach. Researchers are excited about minoxidil because it is traditionally known as a blood pressure medication and hair growth treatment, but it may offer a new mechanism of action for fighting cancer. This drug is taken orally, making it potentially more convenient and less invasive compared to intravenous chemotherapy. Additionally, minoxidil’s potential to attack cancer cells in a novel way could open up new avenues for treating this challenging condition.
What evidence suggests that oral minoxidil might be an effective treatment for platinum-resistant ovarian cancer?
Research has shown that oral minoxidil is under investigation as a potential treatment for ovarian cancer that resists standard therapies. Originally used to treat high blood pressure, scientists are exploring its effects on this type of cancer. Limited information exists on its efficacy for ovarian cancer, but it may influence processes that promote cancer growth. Early results suggest it could improve patient response to treatment, though further studies are necessary for confirmation. Participants in this trial will take minoxidil orally each day to assess its effectiveness and safety for this condition.13678
Who Is on the Research Team?
Margaret Liotta, DO
Principal Investigator
Loyola University
Are You a Good Fit for This Trial?
This trial is for adults over 18 with recurrent platinum-resistant ovarian cancer, who can take pills and have an ECOG Performance Status of 2 or less. They must not have had chemo or radiotherapy in the last 4 weeks, be on other trials, have heart failure or disease, be on dialysis, have brain metastases, allergies to minoxidil, or uncontrolled high blood pressure.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive oral minoxidil daily for the treatment of recurrent platinum resistant ovarian cancer
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Minoxidil
Find a Clinic Near You
Who Is Running the Clinical Trial?
Loyola University
Lead Sponsor
Cures Within Reach
Collaborator
Medical University of South Carolina
Collaborator