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Protein Concentrate

APIC-CF 4cc, for Osteoarthritis

Phase 1 & 2
Waitlist Available
Research Sponsored by Cytonics Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 week
Awards & highlights

Study Summary

The mechanism of Osteoarthritis (OA) is complex, however the investigators know that cartilage breakdown follows changes in certain cells in the cartilage called chondrocytes, leading to proteases that break down cartilage. There is a protein in the human blood called alpha-2-macroglobulin that can trap these proteases and prevent the breakdown of cartilage. Cytonics developed a device that use the patient's own blood to remove all cells and concentrate alpha-2-macroglobulin to be injected in the painful knee due to osteoarthritis.

Eligible Conditions
  • Osteoarthritis
  • Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Reduction in pain after 8 weeks
Reduction in pain while walking at 8 weeks
Secondary outcome measures
Reduction in pain after 2 weeks
Reduction in pain at 24 weeks
Reduction in pain while walking after 24 weeks
+1 more

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: APIC-CF, 2ccExperimental Treatment1 Intervention
APIC-CF, 2cc, one at first day
Group II: APIC-CF 4cc,Experimental Treatment1 Intervention
APIC-CF 4cc, once at first day
Group III: SalinePlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

Cytonics CorporationLead Sponsor
3 Previous Clinical Trials
322 Total Patients Enrolled
1 Trials studying Osteoarthritis
22 Patients Enrolled for Osteoarthritis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
APIC-CF Therapy for Mild to Moderate Osteoarthritis of the Knee
2015. "APIC-CF Therapy for Mild to Moderate Osteoarthritis of the Knee". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02210468.
All > Arthritis > Oa
~30 spots leftby Apr 2025
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