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LY3857210 for Osteoarthritis (OA05 Trial)

Phase 2
Waitlist Available
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Have a visual analog scale (VAS) pain value ≥40 and <95 during screening.
Have a history of daily pain for at least 12 weeks based on participant report or medical history.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to week 8
Awards & highlights

OA05 Trial Summary

This trial tests a new drug to see if it relieves pain in those with osteoarthritis.

Eligible Conditions
  • Osteoarthritis of the Knee

OA05 Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have pain rated between 40 and 95 on a scale during the screening process.
Select...
You have experienced daily pain for at least 12 weeks, based on your own report or your medical history.
Select...
You have been experiencing pain in your knee for more than 12 weeks before the screening.

OA05 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to week 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to week 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain
Secondary outcome measures
Change from Baseline for Disease State Assessment (DSA)
Change from Baseline for Emotional Functioning as measured by the EuroQol-5D-5-Level Questionnaire (EQ-5D-5L)
Change from Baseline for Overall improvement as Measured by Patient's Global Impression of Change
+10 more

OA05 Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: LY3857210Experimental Treatment1 Intervention
LY3857210 will be given orally
Group II: PlaceboPlacebo Group1 Intervention
Placebo will be given orally
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LY3857210
2022
Completed Phase 2
~430

Find a Location

Who is running the clinical trial?

Eli Lilly and CompanyLead Sponsor
2,605 Previous Clinical Trials
3,199,523 Total Patients Enrolled
24 Trials studying Osteoarthritis
5,233 Patients Enrolled for Osteoarthritis
Study DirectorEli Lilly and Company
1,338 Previous Clinical Trials
403,698 Total Patients Enrolled
9 Trials studying Osteoarthritis
2,146 Patients Enrolled for Osteoarthritis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many healthcare facilities have been approved to carry out this experiment?

"The trial is being operated in 28 different locations, such as Arizona Research Center based in Phoenix, Suncoast Research Group located near Miami, and Synexus Clinical Research US Inc. situated in Chandler."

Answered by AI

Are there vacancies in this clinical venture for participants?

"Clinicaltrials.gov reveals that, as of November 11th 2022, this particular medical trial is no longer accepting applications from prospective participants. The original post date was 22nd November 2022. However, 1084 trials are still actively recruiting individuals at this time."

Answered by AI

Has the FDA sanctioned LY3857210 for usage?

"With clinical evidence backing its safety, our experts at Power rated LY3857210 with a score of 2 given that this is still a Phase 2 trial, which means there's no data yet to support efficacy."

Answered by AI

Who else is applying?

What state do they live in?
Florida
Texas
California
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
1
2
3+
What site did they apply to?
FutureSearch Trials of Neurology
Artemis Institute for Clinical Research

Why did patients apply to this trial?

My ortho suggested total knee replacement and I would like to find an alternative if possible.
PatientReceived no prior treatments
I actually have osteoarthritis on knee and both shoulders. I have had both hips repladced already. I am afraid that this is a condition that will render me unable continue athletics.
PatientReceived no prior treatments
~63 spots leftby Mar 2025