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Senolytic Supplement

Low-dose/sustained-duration Fisetin for Osteoarthritis (ROPE Trial)

Phase 1 & 2
Waitlist Available
Led By Austin Stone, MD, PhD
Research Sponsored by Austin V Stone
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Are ambulatory as defined by ability to complete functional performance testing;
Radiographic evidence of Kellgren-Lawrence grade II-IV osteoarthritis in one or both knees;
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3-month follow-up
Awards & highlights

ROPE Trial Summary

This study is evaluating whether a supplement may help treat knee osteoarthritis.

Eligible Conditions
  • Osteoarthritis

ROPE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

ROPE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3-month follow-up
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3-month follow-up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in markers of kidney toxicity
Change in markers of liver toxicity
Change in markers of tumor lysis syndrome
Secondary outcome measures
Cartilage
Senility
Five times sit-to-stand test
+2 more
Other outcome measures
Need for rescue treatment
Treatment Adherence

ROPE Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Low-dose/sustained duration Fisetin (FIS-lo)Experimental Treatment1 Intervention
Group II: High-dose/short-duration Fisetin (FIS-hi)Experimental Treatment1 Intervention
Group III: PlaceboPlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalOTHER
1,605 Previous Clinical Trials
11,467,296 Total Patients Enrolled
16 Trials studying Osteoarthritis
29,873 Patients Enrolled for Osteoarthritis
Austin V StoneLead Sponsor
4 Previous Clinical Trials
74 Total Patients Enrolled
1 Trials studying Osteoarthritis
30 Patients Enrolled for Osteoarthritis
Austin Stone, MD, PhDPrincipal InvestigatorUniversity of Kentucky
3 Previous Clinical Trials
69 Total Patients Enrolled
1 Trials studying Osteoarthritis
30 Patients Enrolled for Osteoarthritis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE)
Austin V Stone 2023. "Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04770064.
~0 spots leftby May 2024
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