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LY3305677 for Obesity

Phase 2
Recruiting
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Have a BMI ≥27 kg/m²and <30 kg/m² with at least one weight-related comorbidity such as hypertension on blood pressure (BP)-lowering medication, dyslipidemia on lipid-lowering medication, cardiovascular (CV) disease, or obstructive sleep apnea
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to week 48
Awards & highlights

Study Summary

This trial creates a framework to evaluate the safety and efficacy of weight management interventions. Different interventions can be tested independently.

Who is the study for?
This trial is for adults with obesity, defined as having a BMI ≥30 kg/m², or overweight individuals (BMI ≥27 kg/m² and <30 kg/m²) with weight-related health issues like high blood pressure on medication, cholesterol problems on drugs, heart disease, or sleep apnea. Participants should have maintained their body weight within a 5% range in the past 3 months.Check my eligibility
What is being tested?
The study is testing the safety and effectiveness of various potential treatments for chronic weight management. One group will receive an investigational drug called LY3305677 while another group will get a placebo. The interventions are part of separate appendices that can start at different times.See study design
What are the potential side effects?
Specific side effects aren't listed here but typically include reactions at the injection site, gastrointestinal symptoms like nausea or diarrhea, headaches, fatigue and potentially allergic reactions to components of the treatment.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My BMI is between 27 and 30, and I have a weight-related health issue.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to week 48
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to week 48 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants Allocated to Each ISA

Trial Design

2Treatment groups
Experimental Treatment
Group I: LY3841136 Obesity ISA LAA1Experimental Treatment2 Interventions
Participants will receive LY3841136 or placebo SC. Each ISA will detail the intervention specific analysis.
Group II: LY3305677 Obesity ISA OXA1Experimental Treatment2 Interventions
Participants will receive LY3305677 or placebo subcutaneously (SC). Each ISA will detail the intervention specific analysis.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LY3305677
2017
Completed Phase 1
~180
LY3841136
2022
Completed Phase 1
~150
Placebo
1995
Completed Phase 3
~2670

Find a Location

Who is running the clinical trial?

Eli Lilly and CompanyLead Sponsor
2,620 Previous Clinical Trials
3,216,209 Total Patients Enrolled
55 Trials studying Obesity
50,829 Patients Enrolled for Obesity
Study DirectorEli Lilly and Company

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research project recruiting individuals aged 25 or above?

"This experiment is accepting volunteers aged 18 - 75."

Answered by AI

How widely is this trial being implemented across various locations?

"This experiment is accessible at Headlands Research - Scottsdale in Scottsdale, California, The Institute for Liver Health II dba Arizona Liver Health-Tucson in Tucson, Florida and National Research Institute - Huntington Park in Huntington Park, Hawaii; additional sites are scattered across the nation."

Answered by AI

Has the Food and Drug Administration given its approval to LY3305677 Obesity ISA OXA1?

"Our team at Powers has determined that the safety of LY3305677 Obesity ISA OXA1 is rated a 2, as it is currently in Phase 2 with evidence supporting its security but no data validating efficacy."

Answered by AI

Could I be admitted to this research project?

"To be qualified for selection in this trial, participants must have a BMI above the obesity threshold and should fall within the specified age range of 18 to 75. Currently, 165 individuals are being recruited for participation."

Answered by AI

Are any additional participants being sought for this medical experiment?

"The clinical study, listed on clinicaltrials.gov since November 17th 2023, is not actively recruiting at this time. Nevertheless, there are 1241 other medical studies searching for participants that have yet to be filled."

Answered by AI

Who else is applying?

What site did they apply to?
Headlands Research - Scottsdale
Peninsula Research Associates
The Institute for Liver Health dba Arizona Clinical Trials
Other
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria

Why did patients apply to this trial?

I am obese and would like to try something different. Have tried numerous times to lose weight without success so looking for something new.
PatientReceived no prior treatments
I have tried two diet meds and continue to struggle. I am 51 and my father died of a heart attack at 41. I need to get this weight off.
PatientReceived 2+ prior treatments
I am interested in weight loss drugs. I had good success with Phen Fen and Meridia back in the day and would like to lose at least 20 pounds.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
A Chronic Weight Management Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
2023. "A Chronic Weight Management Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06143956.
All > Paid Studies Las Vegas > Honolulu
~260 spots leftby Jun 2025
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