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PARP Inhibitor

AZD7648 for Cancer

Phase 1 & 2
Waitlist Available
Led By Dr Timothy Yap
Research Sponsored by AstraZeneca
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 12 months
Awards & highlights

Study Summary

This trial is testing a new drug, AZD7648, to see if it can treat cancer either by itself or in combination with other drugs.

Eligible Conditions
  • Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Patients With Adverse Events or Serious Adverse Events
Number of Patients With Dose Limiting Toxicities (DLTs)
Secondary outcome measures
Accumulation Ratio for Area Under Curve (Rac AUC)
Accumulation Ratio for Cmax (Rac Cmax)
Area Under Plasma Concentration-time Curve From Zero to Infinity (AUCinf)
+9 more

Side effects data

From 2022 Phase 1 & 2 trial • 30 Patients • NCT03907969
100%
Dyspnoea
100%
Headache
100%
Tumour pain
100%
Night sweats
100%
Neck pain
100%
80%
60%
40%
20%
0%
Study treatment Arm
Cohort 4: AZD7648 Dose C1 (Monotherapy)
Cohort 1: AZD7648 Dose A (Monotherapy)
Cohort 2: AZD7648 Dose A1 (Monotherapy)
Cohort 3: AZD7648 Dose B1 (Monotherapy)
Cohort 5: AZD7648 Dose D1 (Monotherapy)
Cohort 6: AZD7648 Dose E1 (Monotherapy)
Cohort 7: AZD7648 Dose F1 (Monotherapy)
Cohort 1: AZD7648 Dose C1 + PLD (Combination Therapy)
Cohort 1: AZD7648 Dose C + PLD (Combination Therapy)
Cohort 3: AZD7648 Dose X + PLD (Combination Therapy)
Cohort 2: AZD7648 Dose C2 + PLD (Combination Therapy)

Trial Design

2Treatment groups
Experimental Treatment
Group I: Core Module: AZD7648 MonotherapyExperimental Treatment1 Intervention
AZD7648 will be administered orally on an empty stomach
Group II: Combination Module 1: AZD7648 + PLDExperimental Treatment2 Interventions
AZD7648 will be administered in combination with Pegylated liposomal doxorubicin (PLD)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PLD
2015
Completed Phase 3
~1420
AZD7648
2019
Completed Phase 2
~30

Find a Location

Who is running the clinical trial?

AstraZenecaLead Sponsor
4,265 Previous Clinical Trials
288,605,252 Total Patients Enrolled
ParexelIndustry Sponsor
303 Previous Clinical Trials
100,796 Total Patients Enrolled
Dr Timothy YapPrincipal InvestigatorMD Anderson Cancer Center, 1400 Holcombe Blvd. Houston, Texas, 77030

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does your research project have an upper age limit for participants?

"This trial is recruiting individuals aged 18-130."

Answered by AI

What other researches have been conducted regarding the effects of AZD7648?

"AZD7648 was first studied in 1997 at the Spectrum Health Butterworth Campus, and since then 678 clinical trials have been completed. At present there are 360 active studies worldwide, with a concentration of research occurring in New Haven, Connecticut."

Answered by AI

What is the utmost capacity of participants in this trial?

"At this time, enrollment for the referenced study is closed. Originally posted on October 9th 2019 and last edited November 9th 2022, other options exist with 2376 trials recruiting patients suffering from advanced forms of cancer and 360 studies enrolling participants taking AZD7648 as a treatment option."

Answered by AI

What goals are being pursued through this clinical investigation?

"This clinical trial has two primary objectives. The first is to measure the number of participants with adverse events/serious adverse events over each 28-day cycle, and the second is to characterise AZD7648's pharmacokinetics when given monotherapy or alongside anti-cancer agents by measuring AUC from zero to last measurable concentration (AUCtau), time to reach maximum plasma concentration (Tmax) and progression-free survival (PFS)."

Answered by AI

Are there any opportunities to join this trial currently available?

"Data published on clinicaltrials.gov reveals that this particular medical trial, which began recruitment in October 2019 and ended in November 2022 is no longer accepting applicants. However, a plethora of other trials (2736 to be exact) are still recruiting patients at present."

Answered by AI

Who qualifies for enrollment in this trial?

"To qualify for this medical experiment, participants should possess an advanced form of cancer and be between 18 to 130 years old. A maximum of 30 volunteers will be accepted."

Answered by AI

Has there been precedent for this sort of research before?

"Alfacell first initiated the clinical trials for AZD7648 in 1997, which included 300 participants. Consequently, after successful Phase 3 approval was granted to AZD7648 and as of today, 66 countries across 1941 cities are running 360 active studies related to this medication."

Answered by AI

What therapeutic applications does AZD7648 typically address?

"AZD7648 has been successfully employed to treat various forms of cancer, including lymphoma, Hodgkin's disease, bronchogenic carcinoma and neuroblastoma."

Answered by AI
~5 spots leftby Apr 2025