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Reparixin for Myelofibrosis
Study Summary
This trial will assess the safety and effectiveness of Reparixin in treating patients with intermediate-2 or high-risk primary myelofibrosis, post ET/PV myelofibrosis, or who are ineligible/refuse treatment with JAKi. 26 patients will be enrolled and receive Reparixin 3x/day for 6 cycles (24 wks). Continued treatment if SD is met.
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Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- I had a stem cell transplant less than 100 days ago.It has been over two weeks since my last myelofibrosis treatment.I haven't used any experimental drugs or devices in the last 4 weeks.I have moderate or severe heart disease.I am currently dealing with a serious infection.My stomach or intestines have issues that could affect how a medicine is absorbed.I am not pregnant or breastfeeding.I am able to get out of my bed or chair and move around.I have recovered from previous cancer treatment side effects, except for hair loss.My condition is a type of advanced myelofibrosis diagnosed by specific criteria.My organs are functioning well.I am 18 years old or older.I have not had a heart attack or stroke in the last 6 months.I do not have any serious health or mental conditions that would stop me from joining the study.I have a history of HIV or active hepatitis A, B, or C.I am willing to have a bone marrow biopsy or had one in the last 90 days without any treatments in between.My condition did not improve with JAK inhibitor therapy.I haven't had any cancer except for skin, prostate, or cervical cancer in the last 3 years.
- Group 1: Reparixin
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What potential risks are associated with Reparixin usage?
"Our team at Power assigned Reparixin a safety rating of 2, as there is evidence to back up its safety but none that supports efficacy given it is only in Phase 2."
Are there any available openings for this experiment currently?
"Unfortunately, the clinicaltrials.gov website affirms that this medical trial is no longer recruiting candidates; however, there are a plethora of other studies with open enrollment at present - totalling 2669 different trials. The initial posting date for this study was on May 1st 2023 and it received its most recent update on April 18th 2023."
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