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RP-3500 + Radiation Therapy for Cancer
Study Summary
This trial is testing the safety of a new drug, RP-3500, when given with palliative radiotherapy to people with metastatic solid tumors and a mutation of the ATM gene.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- My cancer has spread and can be treated with radiation.I have health conditions that prevent me from receiving radiation therapy.I can swallow pills without difficulty.I have a genetic mutation in both copies of my ATM gene.I am not receiving any other systemic treatments during this trial.My high blood pressure is not controlled even with treatment.I can take care of myself and perform daily activities.I am currently taking medication that strongly affects liver enzymes or certain drug transporters.My liver function is moderately or severely impaired.My cancer has a mutation in the ATM gene.I have previously been treated with an ATR or DNA-PK inhibitor.I am taking medication that can affect my heart's rhythm.My kidney and liver functions are within the required ranges.I have had radiation therapy on the area to be treated.I have a history of irregular heartbeats or risk factors for them.I am 18 years old or older.I do not have an active, uncontrolled infection and if HIV positive, I am healthy with low risk for AIDS.
- Group 1: RP-3500 in Combination With Standard Radiation Therapy
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many participants are in this trial at most?
"That is accurate. The clinicaltrials.gov website has information revealing that this trial is looking for 74 patients at 7 different locations. The study was originally posted on 9/30/2022 and updated on the same date."
In how many different medical clinics is this clinical study being run today?
"At the moment, patients are being recruited from 7 different locations for this clinical trial. If you enroll, it is advised that you choose a location nearest to you in order to cut down on travel expenses and time."
Are there any patients who have yet to enroll in this clinical trial?
"Yes, the clinical trial is still open to new participants. The original posting was on September 30th, 2020 and there have been no changes since then. They are looking for 74 individuals spread out over 7 sites."
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