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Proton Beam Therapy
Proton Radiation for Brain Cancer
Phase 1 & 2
Waitlist Available
Research Sponsored by Abramson Cancer Center of the University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age greater than 18 years
Patients with WHO grade II tumors, either completely or incompletely excised, or any recurrent tumor
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
Study Summary
This trial is testing whether proton therapy is a safe and effective treatment for people with brain cancer.
Who is the study for?
This trial is for adults over 18 with WHO Grade I-III Meningioma & Hemangiopericytoma brain cancer. Participants must have adequate bone marrow function, not be pregnant or nursing, and agree to use birth control if of childbearing potential. They should not have had prior brain radiation or other cancers (with some exceptions) in the past two years.Check my eligibility
What is being tested?
The study tests Proton radiotherapy's effectiveness and safety on patients with specific brain cancers. It includes a feasibility phase for 12 patients followed by a larger Phase II for an additional 38 patients, comparing results with existing photon therapy data.See study design
What are the potential side effects?
While the summary doesn't specify side effects, proton radiation can generally cause fatigue, skin reactions at treatment sites, hair loss around treated areas, headaches and may temporarily worsen pre-existing symptoms.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am older than 18 years.
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My tumor is WHO grade II, may or may not be fully removed, or has come back.
Select...
My tumor is WHO grade III or a hemangiopericytoma, and it may not have been fully removed.
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I can care for myself but cannot do normal activities or work.
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My diagnosis is a type of brain tumor called meningioma or hemangiopericytoma.
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My blood tests show enough white cells and platelets.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Feasibility and Safety
Secondary outcome measures
Cumulative total dose (Gy) to normal brain tissue
Fatigue - Brief Fatigue Inventory (BFI)
Health Related Quality of Life
+2 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Proton radiationExperimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Proton Radiation
2009
N/A
~170
Find a Location
Who is running the clinical trial?
Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
105,042 Total Patients Enrolled
1 Trials studying Hemangiopericytoma
23 Patients Enrolled for Hemangiopericytoma
Abramson Cancer Center at Penn MedicineLead Sponsor
387 Previous Clinical Trials
145,642 Total Patients Enrolled
1 Trials studying Hemangiopericytoma
23 Patients Enrolled for Hemangiopericytoma
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am older than 18 years.My tumor is WHO grade II, may or may not be fully removed, or has come back.My tumor is WHO grade III or a hemangiopericytoma, and it may not have been fully removed.I have not had any cancer other than skin or thyroid cancer in the past 2 years.I am using birth control or am not of child-bearing age due to menopause or hysterectomy.My tumor is low grade, newly found, not fully removed, or has come back after surgery.I can care for myself but cannot do normal activities or work.My diagnosis is a type of brain tumor called meningioma or hemangiopericytoma.My blood tests show enough white cells and platelets.I have had radiation treatment to my brain.
Research Study Groups:
This trial has the following groups:- Group 1: Proton radiation
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is there a call for participants at the moment in this research project?
"According to the clinicaltrials.gov platform, this medical experiment is not enrolling patients at present. The trial was published on February 4th 2010 and last updated June 16th 2022 - however, fifty other studies are currently welcoming new participants."
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