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Cancer Vaccine

Vaccine Therapy for Melanoma

Phase 1 & 2
Waitlist Available
Research Sponsored by Sidney Kimmel Cancer Center at Thomas Jefferson University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No altered immunocompetence (e.g., immune deficiency disease or immunosuppressive therapy) in patient or household contacts
Histologically proven melanoma that is considered surgically incurable
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial is testing a vaccine to treat metastatic melanoma. The vaccine may help the body build an immune response to kill melanoma cells.

Who is the study for?
This trial is for adults with metastatic melanoma that can't be removed by surgery. Participants must have skin, under-skin, or lymph node metastases, at least three lesions suitable for injection and biopsy, and show an immune response to a recent smallpox vaccine or other antigens. They cannot join if they are pregnant/nursing, have severe kidney/liver disease, weakened immunity (or live with someone who does), received chemotherapy or steroids recently, or have another cancer within the last 3 years.Check my eligibility
What is being tested?
The study is testing a vaccine therapy's ability to stimulate the body's immune system to fight against melanoma cells in patients with advanced skin cancer. It's in Phase I/II which means it’s early in development but also looking at how effective it might be.See study design
What are the potential side effects?
Possible side effects of the vaccine may include reactions at the injection site like redness and swelling, flu-like symptoms such as fever and fatigue, allergic reactions to components of the vaccine preparation could occur.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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Neither I nor anyone in my household has a weakened immune system.
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My melanoma cannot be removed with surgery.
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I showed signs of an immune response within 4 days after getting the smallpox vaccine.
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My cancer has spread to my skin, just under my skin, or lymph nodes.
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I am 18 years old or older.
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I have at least 3 tumors that can be injected and biopsied.
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I am fully active or can carry out light work.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Find a Location

Who is running the clinical trial?

Sidney Kimmel Cancer Center at Thomas Jefferson UniversityLead Sponsor
162 Previous Clinical Trials
10,881 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,662 Previous Clinical Trials
40,925,851 Total Patients Enrolled
Michael J. Mastrangelo, MDStudy ChairSidney Kimmel Cancer Center at Thomas Jefferson University

Media Library

Vaccine Therapy (Cancer Vaccine) Clinical Trial Eligibility Overview. Trial Name: NCT00002817 — Phase 1 & 2
Skin Cancer Research Study Groups:
Skin Cancer Clinical Trial 2023: Vaccine Therapy Highlights & Side Effects. Trial Name: NCT00002817 — Phase 1 & 2
Vaccine Therapy (Cancer Vaccine) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00002817 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research project actively seeking participants?

"According to clinicaltrials.gov, this medical study has concluded its participant search, the initial post being made on April 1st 1996 and last updated January 9th 2014. Nevertheless, 758 other trials are actively recruiting patients at present."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Vaccine Therapy in Treating Patients With Metastatic Melanoma
1996. "Vaccine Therapy in Treating Patients With Metastatic Melanoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00002817.
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~1 spots leftby Apr 2025
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