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Radiation Therapy
MR-Guided Radiotherapy for Cancer
Phase 1 & 2
Recruiting
Led By Nawaid Usmani, MD
Research Sponsored by AHS Cancer Control Alberta
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Adults ≥ 18 years of age
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years after completion of treatment
Awards & highlights
Study Summary
This trial is testing a new way to do radiation therapy that uses MRI scans to better target the cancer.
Who is the study for?
This trial is for adults over 18 who can undergo external beam radiation therapy and are available for follow-up. It's not suitable for those unable to lie still during scans, cannot consent, have inferior treatment plans with this method compared to standard CT, are pregnant, or have MRI contraindications.Check my eligibility
What is being tested?
The Northern LIGHTs-2 study tests a new MR guided radiotherapy technology called Linac-MR. This Phase I/II trial aims to check if the treatment can be completed as planned and assess its effects on cancer and any potential radiation side effects.See study design
What are the potential side effects?
While specific side effects aren't listed, participants may experience expected or unexpected radiation side effects similar to other radiotherapy treatments such as skin irritation, fatigue, nausea or more serious complications depending on the area treated.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years after completion of treatment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years after completion of treatment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Proportion of participants that complete a course of external beam radiotherapy with the Alberta linac-MR P3 system
Secondary outcome measures
Disease-free survival
Acute Coryza
Incidence of late toxicity
+5 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: MR guided radiotherapyExperimental Treatment1 Intervention
MR-guided radiotherapy using the Alberta linac-MR P3 system. Contemporary radiotherapy techniques and fractionation schedules will be conducted in the following graduated stages with overlap between stages allowed:
Stage 1: Parallel-opposed pair treatments (palliative) Stage 2: 4 field box and breast treatments (curative or palliative) Stage 3: Radical treatments - multi-field 3DCRT (curative) Stage 4: Radical treatments - multi-field IMRT (curative)
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Who is running the clinical trial?
AHS Cancer Control AlbertaLead Sponsor
182 Previous Clinical Trials
36,100 Total Patients Enrolled
Nawaid Usmani, MDPrincipal InvestigatorCross Cancer Institute, Alberta Health Services
3 Previous Clinical Trials
351 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am 18 years old or older.I am unable to understand or sign the consent form.My radiation oncologist says I'm fit for external beam radiation therapy.I cannot stay still or lie flat for long periods.My treatment plan is worse than what's usually expected and causes more intense radiation areas.
Research Study Groups:
This trial has the following groups:- Group 1: MR guided radiotherapy
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are people with the relevant medical conditions able to enroll in this trial today?
"No, this particular trial is not currently enrolling patients. Although the clinical trial's last update was on 6/7/2022, indicating it may start again in the future. There are however, 501 other trials that are recruiting right now."
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