Your session is about to expire
← Back to Search
Chemotherapy
Gene Therapy + Chemotherapy for Non-Hodgkin's Lymphoma
Phase 1 & 2
Waitlist Available
Research Sponsored by Systemix
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age: 18 and over
No hepatitis
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying how well RevM10-treated stem cells work in combination with chemotherapy and stem cell transplantation in treating patients with HIV-related non-Hodgkin's lymphoma.
Who is the study for?
Adults over 18 with HIV-related non-Hodgkin's lymphoma responding to chemotherapy but not in complete remission, or those relapsing after treatment. Must have a certain level of blood cells and organ function, no active major infections or recent substance abuse, and agree to use contraception.Check my eligibility
What is being tested?
The trial is testing gene therapy using RevM10-modified stem cells combined with chemotherapy and peripheral stem cell transplantation to see if it can better fight cancer or make the cancer more sensitive to treatment in patients with HIV-related lymphoma.See study design
What are the potential side effects?
Potential side effects may include typical reactions from chemotherapy such as nausea, fatigue, hair loss, increased risk of infection due to low blood counts; complications from stem cell transplant like graft-versus-host disease; and possible unknown effects from the gene therapy.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Select...
I do not have hepatitis.
Select...
I do not have lymphoma in my brain or spinal cord.
Select...
My lymphoma is responding to chemotherapy.
Select...
I do not have uncontrolled lymphoma in the lining of my brain or spinal cord.
Select...
My cancer improved but did not fully go away after 4 standard chemotherapy treatments.
Select...
My cancer came back but responded to the initial treatment.
Select...
My bilirubin level is below 2 mg/dL.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Find a Location
Who is running the clinical trial?
SystemixLead Sponsor
National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,933,138 Total Patients Enrolled
1,381 Trials studying Lymphoma
382,385 Patients Enrolled for Lymphoma
Tyler Martin, MDStudy ChairSystemix
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- It has been over a year since I had any brain-related disease or seizures.I have had a condition where my lymphocytes grow abnormally.I am 18 years old or older.I do not have hepatitis.I have a history of cancer.I do not have lymphoma in my brain or spinal cord.My lymphoma is responding to chemotherapy.I do not have uncontrolled lymphoma in the lining of my brain or spinal cord.My health status matches the required disease characteristics.I haven't had cancer in the last 5 years, except for skin cancer.I have high LDH, am in stage III or IV, or have a low ability to do daily activities.My cancer improved but did not fully go away after 4 standard chemotherapy treatments.My cancer came back but responded to the initial treatment.My bilirubin level is below 2 mg/dL.I have been sober from alcohol or drugs for at least 6 months.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How many different medical clinics are participating in this study?
"University of Alabama Comprehensive Cancer Center in Birmingham, Cedars-Sinai Medical Center in Boston, and Massachusetts General Hospital Cancer Center in Omaha are a few examples of the 6 sites recruiting patients for this clinical trial."
Answered by AI
Are new volunteers still being taken for this clinical research?
"No, this particular trial is not looking for patients at the moment. However, it is worth noting that there are nearly 2000 other active clinical trials that might be a match for you."
Answered by AI
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger