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Platinum-containing Compound

Sodium Thiosulfate for Central Nervous System Lymphoma

Phase 1 & 2

Waitlist Available

Led By Edward A Neuwelt

Research Sponsored by OHSU Knight Cancer Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from entry onto study until death from any cause, assessed at 2 years

Awards & highlights

Study Summary

This trial is testing methotrexate, mannitol, rituximab, and carboplatin to treat primary central nervous system lymphoma. The drugs work in different ways to stop cancer growth. Giving them together may be effective.

Eligible Conditions

Central Nervous System Lymphoma

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from entry onto study until death or progression of disease, assessed at 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from entry onto study until death or progression of disease, assessed at 2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and from entry onto study until death or progression of disease, assessed at 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

CR rate (Phase II)

Incidence of toxicities, assessed using National Cancer Institute Common Toxicity Criteria for Adverse Events version 3.0 (Phase I)

Secondary outcome measures

Event-free survival

Overall survival

Trial Design

1Treatment groups

Experimental Treatment

Group I: Treatment (rituximab, mannitol, methotrexate, carboplatin)Experimental Treatment6 Interventions

Patients receive rituximab IV over 5 hours on day 1, mannitol IA, methotrexate IA over 10 minutes, and carboplatin IA over 10 minutes on days 2 and 3. Patients then receive sodium thiosulfate IV over 15 minutes at 4 and 8 hours after carboplatin. Treatment repeats monthly for up to 12 courses in the absence of disease progression or unacceptable toxicity.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Methotrexate

FDA approved

Thiosulfuric acid

FDA approved

Carboplatin

FDA approved

Mannitol

FDA approved

Rituximab

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH

13,672 Previous Clinical Trials

40,926,721 Total Patients Enrolled

7 Trials studying Central Nervous System Lymphoma

347 Patients Enrolled for Central Nervous System Lymphoma

Oregon Health and Science UniversityOTHER

974 Previous Clinical Trials

7,385,831 Total Patients Enrolled

OHSU Knight Cancer InstituteLead Sponsor

230 Previous Clinical Trials

2,090,645 Total Patients Enrolled

1 Trials studying Central Nervous System Lymphoma

155 Patients Enrolled for Central Nervous System Lymphoma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Might I be eligible to enroll in this clinical trial?

"The current clinical trial has 81 open slots for patients that have lymphoma and are between 18-75 years old."

Answered by AI

Does this research project only allow people under the age of 25 to participate?

"The patients that this study are recruiting must have surpassed their 18th birthday but cannot be older than 75 years old."

Answered by AI

Are patients currently being recruited for this clinical trial?

"Recruitment for this study has stopped. However, it was first posted on 10/14/2005 and was last edited on 9/15/2021. There are many other ongoing trials that might be of interest; presently, there are 1760 active lymphoma studies and 1331 Sodium Thiosulfate studies recruiting patients."

Answered by AI

How many individuals are being researched in this clinical trial?

"This study is no longer recruiting patients. The original posting date was October 14th, 2005 and the most recent update was September 15th, 2021. There are currently 1760 lymphoma studies and 1331 Sodium Thiosulfate trials that are actively enrolling participants."

Answered by AI

What medical conditions is Sodium Thiosulfate commonly used to treat?

"Sodium Thiosulfate is a medication used to lower intraocular pressure and treat other conditions like small cell lung cancer and advanced testicular cancer."

Answered by AI

Can you please provide more information on other scientific research projects that have used Sodium Thiosulfate?

"Right now, there are 383 Sodium Thiosulfate trials in Phase 3 out of the 1331 ongoing clinical research studies. Most of these New york based trials are 66325 location studies."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma

Edward Neuwelt 2005. "Methotrexate, Mannitol, Rituximab, and Carboplatin in Treating Patients With Newly Diagnosed Primary Central Nervous System Lymphoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00293475.