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Anti-metabolites

Evorpacept + Venetoclax + Azacitidine for Acute Myeloid Leukemia

Phase 1 & 2
Waitlist Available
Research Sponsored by ALX Oncology Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approximately 6 months
Awards & highlights

Study Summary

This trial will test a new combination therapy for treating patients with acute myeloid leukemia.

Eligible Conditions
  • Acute Myeloid Leukemia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approximately 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Phase 1: Dose Limiting Toxicities (DLT)
Phase 2: Composite complete remission rate (CRc)

Trial Design

1Treatment groups
Experimental Treatment
Group I: evorpacept (ALX148) + venetoclax + azacitidineExperimental Treatment3 Interventions
Phase 1a: Participants will receive escalating doses of evorpacept (ALX148) in combination with venetoclax and azacitidine Phase 1b/2: Participants will receive evorpacept (ALX148) at the recommended Phase 2 dose in combination with venetoclax and azacitidine
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
venetoclax
2021
Completed Phase 2
~750
azacitidine
2005
Completed Phase 3
~1740

Find a Location

Who is running the clinical trial?

ALX Oncology Inc.Lead Sponsor
8 Previous Clinical Trials
1,243 Total Patients Enrolled

Media Library

Azacitidine (Anti-metabolites) Clinical Trial Eligibility Overview. Trial Name: NCT04755244 — Phase 1 & 2
Acute Myeloid Leukemia Research Study Groups: evorpacept (ALX148) + venetoclax + azacitidine
Acute Myeloid Leukemia Clinical Trial 2023: Azacitidine Highlights & Side Effects. Trial Name: NCT04755244 — Phase 1 & 2
Azacitidine (Anti-metabolites) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04755244 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you provide a breakdown of the medical centers participating in this trial across the state?

"Currently, this clinical trial is enrolling patients from 5 different sites. These locations are Buffalo, Chicago and Nashville in addition to 2 other cities. To reduce travel expenses for participants, it would be prudent to choose the closest medical centre."

Answered by AI

What utilization is most common for evorpacept?

"Evorpacept is a commonly used medication for induction chemotherapy. Furthermore, it has been effective in treating refractory anemias, leukemia, myelocytic forms of acute and multilineage dysplasia."

Answered by AI

Are there any current opportunities to join this exploratory research?

"As indicated on clinicaltrials.gov this trial, initially posted 5/5/2021 and last updated 6/7/2022, is not currently accepting new participants. Nonetheless, there are 1,879 other studies actively searching for volunteers at the moment."

Answered by AI

How many participants are enrolled in this experiment?

"Unfortunately, this trial is no longer enrolling participants. It was initially posted on May 5th 2021 and had its last update on June 7th 2022. If you are looking for a different study to join, there are 1539 trials actively recruiting patients with leukemia or myeloid diseases and 340 studies that accept enrollees for evorpacept treatment."

Answered by AI

Has there been any precedent for research utilizing evorpacept?

"The initial research of evorpacept commenced at the Chinese University of Hong Kong-Prince of Wales Hospital in 2006, with 208 trials having been completed to date. Currently there are 340 ongoing investigations, and numerous sites located in Buffalo, New york are participating."

Answered by AI
~25 spots leftby Apr 2025