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Tetracycline Antibiotic

Minocycline for Drug-Resistant High Blood Pressure

Phase 1 & 2
Waitlist Available
Led By Carl Pepine, MD
Research Sponsored by University of Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Greater than 18 and less than 86 years of age
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in baseline to week 54
Awards & highlights

Study Summary

This trial is testing whether minocycline, a drug typically used to treat acne, can help to lower blood pressure in people who have hypertension that doesn't respond well to other treatments.

Who is the study for?
This trial is for adults aged 18-85 with high blood pressure that's not controlled despite taking three different anti-hypertensive drugs, including a diuretic. Participants must have stable medication doses and an office systolic blood pressure over 160 mmHg. Pregnant women or those with heart failure, severe diseases like cancer or HIV/AIDS, recent cardiovascular events, certain arrhythmias, or using NSAIDs can't join.Check my eligibility
What is being tested?
The study tests if Minocycline can lower blood pressure in patients whose hypertension doesn't respond to standard treatments. It's a double-blind trial where participants randomly receive either Minocycline or a placebo without knowing which one they're getting.See study design
What are the potential side effects?
Minocycline may cause side effects such as dizziness, fatigue, digestive issues like nausea or diarrhea, skin reactions like rashes and itching. There might also be risks of more serious conditions affecting the liver or causing drug hypersensitivity.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are between 18 and 85 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in baseline to week 54
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in baseline to week 54 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Reduction of ambulatory blood pressure

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Minocycline GroupActive Control1 Intervention
These subjects will start with minocycline for 16 weeks, followed by a washout period for 3 weeks, then will receive a placebo for 16 weeks, followed by a washout period for 3 weeks, then will finish with minocycline for 16 weeks.
Group II: Placebo GroupPlacebo Group1 Intervention
These subjects will start with placebo (this will look like minocycline) for 16 weeks, followed by a washout period for 3 weeks, then will receive a minocycline for 16 weeks, followed by a washout period for 3 weeks, then will finish with placebo for 16 weeks.

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH
3,830 Previous Clinical Trials
47,302,754 Total Patients Enrolled
University of FloridaLead Sponsor
1,339 Previous Clinical Trials
717,355 Total Patients Enrolled
Carl Pepine, MDPrincipal InvestigatorUniversity of Florida
6 Previous Clinical Trials
225 Total Patients Enrolled

Media Library

Minocycline (Tetracycline Antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT02133885 — Phase 1 & 2
High Blood Pressure Research Study Groups: Minocycline Group, Placebo Group
High Blood Pressure Clinical Trial 2023: Minocycline Highlights & Side Effects. Trial Name: NCT02133885 — Phase 1 & 2
Minocycline (Tetracycline Antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02133885 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are seniors within the specified age range able to apply for this research?

"This medical study is open to prospective participants aged 18 and over, up until 85 years of age."

Answered by AI

What indications is the Minocycline Group commonly prescribed to treat?

"Minocycline Group is a popular treatment for Rocky Mountain spotted fever and has been prescribed to combat other ailments such as q fever, dental root planing, and respiratory tract infections."

Answered by AI

Are there current vacancies for participants in this clinical trial?

"This clinical trial is no longer accepting applications. Initially posted on December 1st 2022, the study was last edited on May 23rd 2022. If you are searching for other trials, 746 studies involving hypertension have open enrollment and 21 medical research projects studying Minocycline Group require more participants."

Answered by AI

May I participate in this experiment?

"This clinical trial is enrolling 56 participants who are afflicted with hypertension and aged between 18 to 85. To become part of the study, applicants need to fulfill a few requirements; they must be over 18 years old but under 86, take three or more medicines from different drug classes (one being diuretic) for at least two months without any changes, agree to follow all procedures within the experiment, provide written consent if female and not pregnant, have estimated glomerular filtration rate above 45 ml/min per 1.73 m2 using MDRD calculation ,and no history of inpatient hospitalization due to anti-hy"

Answered by AI

Has Minocycline Group been the subject of prior experiments?

"At present, a total of 21 Minocycline Group studies are underway with 6 in the late-stage Phase 3. Many trials for this particular drug occur in Guangzhou, Guangdong yet there are 37 additional sites where research is being conducted."

Answered by AI

What is the current enrollment capacity for this research endeavor?

"This trial has reached its recruitment quota and is no longer accepting applicants. It was initially announced on December 1st, 2022 and last updated on May 23rd of the same year. Nevertheless, if you are still keen to take part in medical studies, there are currently 746 trials for hypertension patients as well as 21 Minocycline Group experiments that require volunteers."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients
2023. "Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02133885.
~0 spots leftby Apr 2025
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