Arm 2 for Hypersensitivity

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Study Site, Cincinnati, OH
Hypersensitivity+2 More
Eligibility
< 65
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a drug may help treat food allergies.

See full description

Eligible Conditions

  • Hypersensitivity
  • Food Allergy

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Hypersensitivity

Study Objectives

This trial is evaluating whether Arm 2 will improve 1 primary outcome in patients with Hypersensitivity. Measurement will happen over the course of Week 40.

Week 40
Food Allergy Desensitization

Trial Safety

Safety Progress

1 of 3

Other trials for Hypersensitivity

Trial Design

2 Treatment Groups

Arm 2
1 of 2
Arm 1
1 of 2
Experimental Treatment

This trial requires 73 total participants across 2 different treatment groups

This trial involves 2 different treatments. Arm 2 is the primary treatment being studied. Participants will be divided into 2 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.

Arm 2
Biological
Arm 1
Biological

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: week 40
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly week 40 for reporting.

Closest Location

Study Site - Cincinnati, OH

Eligibility Criteria

This trial is for patients born any sex aged 65 and younger. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Experience dose-limiting symptoms at or below the 100-mg dose level to 1 or multiple food sources in ADP101
Age 4 to 55 (inclusive)
Clinical history of allergy to at least 1 of the foods contained in ADP101

Patient Q&A Section

How many people get food hypersensitivity a year in the United States?

"Recent findings shows that food hypersensitivity is common among US adults, with up to 9% of the population afflicted in a given year. The rate of reaction and reaction severity will vary based on the food ingested and will be influenced by multiple predisposing and modifying factors. These factors include genetics, food protein content and composition, oral hygiene, and the patient's state of immune function." - Anonymous Online Contributor

Unverified Answer

What are the signs of food hypersensitivity?

"Some of the signs of food hypersensitivity are wheezing, difficulty breathing, vomiting, swelling of the face and eyes, facial discoloration, and difficulty with swallowing, etc. There is a wide gap in knowledge of all the allergies. Better training and education for doctors should be developed to treat allergic diseases. The management of allergic diseases is of utmost importance for the survival of patients and their families." - Anonymous Online Contributor

Unverified Answer

What is food hypersensitivity?

"There are many possible hypersensitizations to food ingredients, but there is only one specific form of food hypersensitivity. Food sensitizations can be treated by eliminating foods with dietary ingredients that cause symptoms. This is done through a process called food provocation. Food allergies can be managed through exclusion diets: by avoiding or eliminating food(s) to which one is allergic. Food intolerances cannot be eliminated through elimination diets. Many food intolerances are caused by an overgrowth of certain types of bacteria or fungi, which invade the gastrointestinal tract. Food sensitivities and food intolerances do not always manifest in the same ways and it is important to have an understanding of how the body is responding to food substances in order to treat the symptoms." - Anonymous Online Contributor

Unverified Answer

Can food hypersensitivity be cured?

"Data from a recent study highlights the importance of food allergy as a cause of food hypersensitivity and emphasises the need for food allergy education to be integrated into the management of food hypersensitivity disorders." - Anonymous Online Contributor

Unverified Answer

What causes food hypersensitivity?

"Results from a recent paper provided an insight into the causal factors underlying food hypersensitivity. Although other factors, such as individual and family-wise exposures, may contribute to food hypersensitivity, this study showed that exposure to allergen sources plays a major role in the etiology of food hypersensitivity." - Anonymous Online Contributor

Unverified Answer

What are common treatments for food hypersensitivity?

"Most of the common hypersensitivity symptoms to dietary causes are treated with nutritional therapy. However, as most dietary-related symptoms are self-limited, there is a low rate of dietary avoidance required to prevent recurrence. The management of food hypersensitivity can be complicated by a delay in diagnosis, as many symptoms may be mistaken for other problems. This situation can result from patients and clinicians often delaying the diagnosis or incorrect diagnoses. Improper diagnoses cause unnecessary dietary modification, and dietary avoidance of the offending dietary cause may be required to prevent recurrence." - Anonymous Online Contributor

Unverified Answer

Does food hypersensitivity run in families?

"The prevalence of food hypersensitivity is comparable with other common conditions, and food hypersensitivity does not seem to run in families. This finding, however, is limited by insufficient power." - Anonymous Online Contributor

Unverified Answer

Is arm 2 typically used in combination with any other treatments?

"Although some physicians routinely treat arm 2, the overall use of arm 2 in the treatment protocol was low, suggesting that doctors do not routinely use arm 2 as routinely." - Anonymous Online Contributor

Unverified Answer

What is the latest research for food hypersensitivity?

"The studies on food hypersensitivity suggest that many of the issues are based upon the definition of intolerance. There is a need to develop consensus definitions for food hypersensitivity, which are needed to test and develop new diagnostic criteria to be used in clinical trials. This, in turn, would help to test new therapeutic options that would make a positive difference on the quality of life of patients with food hypersensitivity." - Anonymous Online Contributor

Unverified Answer

Has arm 2 proven to be more effective than a placebo?

"Arm 2 appeared to be more effective than a placebo in terms of reducing VTE rates and is being considered as a substitute for Arm 1, if Arm 1 is not available at the beginning of treatment. This is a good sign for clinical trials for VTE in the treatment of cancer patients, who are all receiving chemoprevention treatment." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets food hypersensitivity?

"Food hypersensitivity occurs later in adulthood. In this report, people were not shown to have developed food hypersensitivity by age 18. It is recommended that doctors first consider other medical conditions before making a diagnosis of food hypersensitivity.\n" - Anonymous Online Contributor

Unverified Answer

What are the common side effects of arm 2?

"In the long term, the common side effects of arm 2 are: numbness, tingling of skin and fascia, atrophy, pain, weakness, and a burning sensation. The common side effects of arm 2 are: numbness, tingling of skin and fascia, atrophy, weakness, and a burning sensation. It is necessary for patients with arm 2 to wear padded protective clothing and not to expose the arm to cold air. Arm 2 is not usually painful, but one-fifth of patients with arm 2 report a burning sensation." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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