Microbiota Transplant Therapy for Hepatic Encephalopathy
(MASTERPIECE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to find out whether changing the microbes in the bowels of Veterans with cirrhosis and hepatic encephalopathy (a condition that affects the brain as a result of liver problems) using capsules made from microbes from healthy people can prevent future episodes of hepatic encephalopathy.
Who Is on the Research Team?
Jasmohan S. Bajaj, MD MS
Principal Investigator
Richmond VA Medical Center, Richmond, VA
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive microbiota transplant therapy (MTT) or placebo capsules twice a day for 2 weeks
Follow-up
Participants are monitored monthly for recurrence of hepatic encephalopathy and other outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Microbiota transplant therapy (MTT) capsules
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Microbiota transplant therapy (MTT) capsules
Placebo capsule
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor
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