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Hormone Therapy

Order 2 for Healthy Adults (POPP Trial)

Phase 2
Waitlist Available
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1 and day 2
Awards & highlights

POPP Trial Summary

This trialwill examine how oxytocin injections affect how we perceive gentle stroking and pain, and how this hormone affects the nerves in our skin.

POPP Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1 and day 2
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 and day 2 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in mean pleasantness rating of gentle brushing
Change in mechanical threshold
Change in temporal summation of pinprick stimuli
Secondary outcome measures
Anxiety using the State-Trait Anxiety Inventory
Attention to body using the The Body Awareness Questionnaire
Autistic traits using the Autism Quotient
+6 more

Side effects data

From 2020 Phase 2 trial • 42 Patients • NCT03016598
6%
Constipation
6%
Stinging sensation
100%
80%
60%
40%
20%
0%
Study treatment Arm
Oxytocin
Placebo

POPP Trial Design

2Treatment groups
Experimental Treatment
Group I: Order 2Experimental Treatment1 Intervention
Participants will receive 2ml isotonic saline during Session 1 and 4mcg/2ml oxytocin during Session 2, injected into the forearm.
Group II: Order 1Experimental Treatment1 Intervention
Participants will receive 4mcg/2ml oxytocin during Session 1 and 2ml isotonic saline during Session 2, injected into the forearm.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Pitocin
2012
Completed Phase 2
~150

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,120 Previous Clinical Trials
1,521,387 Total Patients Enrolled
2 Trials studying Healthy Adults
33 Patients Enrolled for Healthy Adults

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research accessible to senior citizens?

"The age range for patients eligible to take part in this trial is between 18 and 65 years old."

Answered by AI

Is enrollment into this experiment still available to participants?

"The details posted on clinicaltrials.gov confirms that the trial is actively searching for participants, with an original posting date of March 1st 2023 and a final update occurring January 24th 2023."

Answered by AI

Does my profile qualify me for enrollment in this experiment?

"This research is accepting 20 participants within the 18-65 age range that are verbally fluent in English and possess a sound bill of health."

Answered by AI

Has Order 1 been granted regulatory approval by the FDA?

"Our team at Power judged the safety of Order 1 to be a 2 due to its Phase 2 trial status. This implies that there is some data showing safety, yet no evidence backing efficacy."

Answered by AI

What is the cap for participants in this investigation?

"Affirmative. According to clinicaltrials.gov, this medical experimentation is actively recruiting participants who were first notified of the trial on March 1st 2023 and updated on January 24th 2023. At present, they are searching for a total of 20 people from one centre alone."

Answered by AI

What aims is this clinical trial aiming to fulfill?

"This two-day experiment is designed to measure the change in perceived pleasantness of gentle brushing. Supplementary evaluations include heat pain ratings, through use of a Visual Analog Scale with "No pain" and "Most intense pain imaginable" anchors; Heat Pain Threshold (HPT), assessed via thermode increases on the arm until reported as painful by participants; and Pain Anxiety Symptoms Scale short form, used to gauge whether oxytocin has an effect on physical touch perception."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Peripheral Oxytocin and Touch
Laura Case 2023. "Peripheral Oxytocin and Touch". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05326776.
~10 spots leftby Apr 2025
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