Treatment for Head Neoplasms

1 Prior Treatment
Stage III
Waitlist Available · 18+ · All Sexes · Kansas City, KS

This study is evaluating whether a combination of drugs can be used to treat head and neck cancer.

See full description

About the trial for Head Neoplasms

Eligible Conditions
Head and Neck Neoplasms · Head and Neck Cancer

Treatment Groups

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.


This trial is for patients born any sex aged 18 and older. You must have received 1 prior treatment for Head Neoplasms or the other condition listed above. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
by RECIST Stage III or IV squamous cell carcinoma of the head and neck that cannot be surgically removed and is not cured with radiation therapy is limited to the upper aerodigestive tract show original
The patient must be over 18, have a performance status of SWOG 0-2, a life expectancy not specified, hematopoietic function not specified, hepatic function with bilirubin no greater than 3 times institutional normal and transaminases no greater than 3 times institutional normal, renal function with creatinine clearance greater than 40 mL/min, cardiac function with adequate cardiac function and no heart failure, pulmonary function with adequate pulmonary function not requiring supplemental oxygen, and be not pregnant or fertile and using adequate contraception. show original
Some prior concurrent therapy is allowed, including radiation therapy, surgery, and biologic therapy, but not chemotherapy or endocrine therapy. show original
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Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Up to 5 years
Screening: ~3 weeks
Treatment: Varies
Reporting: Up to 5 years
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Up to 5 years.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the average age someone gets head neoplasms?

The prevalence of head neoplasms increases rapidly after age 20 and slows down after age 50. The age-specific occurrence of head neoplasms suggests that it is most likely a neoplastic disease associated with aging rather than a congenital disease. Future research should focus on modifying the biological/environmental changes that occur with aging in order to prevent or delay the onset of head neoplasms.

Anonymous Patient Answer

What is head neoplasms?

Head neoplasms is a term for cancer lesions that form in the scalp and the forehead. The incidence of scalp and frontal head cancer has been slowly rising during the last 25 years due to ageing of the population. Head and neck cancer has long been a part of the medical profession's knowledge about neoplasms but it has only recently been a topic for academic research. The authors have analyzed clinical trials related to head and neck cancer and the findings from the trials and research studies, which have been published in the medical literature during the last decade, are reviewed with regard to the nature of the therapeutic approach, the current knowledge about the natural history of the disease and the need for further studies in order to develop novel therapeutic strategies.

Anonymous Patient Answer

Can head neoplasms be cured?

The development of surgical techniques (oncology), the development of radiation beams, and the evolution of chemotherapy have had a significant impact on the survival of these patients.

Anonymous Patient Answer

What causes head neoplasms?

The most common causes of [head and neck cancer]( in the United States are UV exposure from the sun, HPV, and tobacco use. Sunburn in the face or head can also cause skin cancers. The use of tobacco may affect the blood vessels supplying the head and neck and cause skin, liver and lung cancers. Many cancers in the head and neck area are inherited, such as hereditary squamous cell carcinoma. Cancer can be caused by cancers of the digestive organs such as pancreas, stomach, colon, liver, and lymphoma. A variety of other cancers occur in the head and neck area. Cancers that affect the ear, nose, throat and sinuses can develop by infection by viruses such as Human Papilloma Virus.

Anonymous Patient Answer

How many people get head neoplasms a year in the United States?

The number of people with head neoplasms is increasing. The number of cases is higher in men. A significant number of people with head neoplasms, although less than 20% of new cancers that affect the head, will have head and neck cancer for which most would have been previously untreated if head and neck cancers had been treated.

Anonymous Patient Answer

What are the signs of head neoplasms?

A head trauma is frequently associated with neoplasms in both the brain and other cranial cavity, especially the dura--this is extremely important because of the low sensitivity of CT scan. In cases of head trauma and a history of neoplasms, follow-up is necessary and, if necessary, surgery.

Anonymous Patient Answer

What are common treatments for head neoplasms?

Treatment of head neoplasms depends upon the histology at presentation, tumor grade and extent of spread. We summarize typical treatment options for common head neoplasms (astrocytomas, meningioma, choroid plexus tumors, pituitary adenomas) and common recurrent neoplasms (meningoangiomatosis, chordoma, glioblastoma, craniopharyngioma). A number of additional common benign and borderline histologies that require treatment are listed. We expect that the availability of treatment algorithms similar to the one described will help health professionals to improve patient care by better identifying and treating these tumors.

Anonymous Patient Answer

Is treatment typically used in combination with any other treatments?

The use of combination therapy with two or many new agents seems to be more frequent in the last decade. The number of trials in a given patient population will hopefully grow according to an increasing number of patients with non-metastatic head and neck cancer. For patients in whom new therapeutic agents have proved to be less effective, other therapeutic approaches may be considered.

Anonymous Patient Answer

Has treatment proven to be more effective than a placebo?

Results from a recent paper show that patients need a control group when comparing different treatments to measure a placebo effect. It was also demonstrated that when comparing treatments where a placebo effect is present a treatment with a negative effect may be more effective than a positive effect to stop the side effects of an already-established treatment. This placebo effect may be used when evaluating new treatment schemes.

Anonymous Patient Answer

What are the chances of developing head neoplasms?

In a recent study, findings show that patients who develop head tumors are more likely to develop brain tumors and parotid tumors than other patients with head neoplasms. We found no significant difference in the occurrence of patients with head neoplasms who are carriers of the BRCA mutation.

Anonymous Patient Answer

Who should consider clinical trials for head neoplasms?

Clinical trials are an effective tool to determine the efficacy and safety of medical therapies in patients with head neoplasms; however, not all patients who could benefit from a particular therapy and who would likely benefit from such treatment would participate in and complete such treatment because of concerns about safety and costs. Further, in some patients, clinical trials may be harmful, even though such treatments may be needed and would be beneficial. Therefore, clinical trials should be designed and conducted cautiously and with a thorough understanding of the limitations and considerations of the risks involved.

Anonymous Patient Answer

What does treatment usually treat?

Recent findings concludes that the disease in patients’ head is the most common of its kind, as the most common form of head and neck cancer and that the treatment of head and neck cancer is most efficient.

Anonymous Patient Answer
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