This trial is evaluating whether Mebendazole will improve 2 primary outcomes and 5 secondary outcomes in patients with Pilocytic Astrocytoma. Measurement will happen over the course of Assessed after the 10 week Induction cycle.
This trial requires 36 total participants across 2 different treatment groups
This trial involves 2 different treatments. Mebendazole is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
"About 43,000 people would be diagnosed with a glioma in the United States each year. This is 14% of the population. The peak age for glioma to occur is age 60 years. There is also an increasing trend in glioma incidence (increasing rates) which has been seen in at least the past decade for men and women." - Anonymous Online Contributor
"The cause of glioma is still unknown, but in most cases, it is a consequence of either a genetic and/or exposure-related anomaly, with no single cause as yet identified. In many cases, glioma appears to be a consequence of a benign lesion, and a number of genetic lesions have been shown to cause a subset of cases. Gliomas may also develop de novo from a normal brain, which is termed "de novo" astrocytomas or "de novo" oligodendroglioma." - Anonymous Online Contributor
"The pathogenesis of glioma has been investigated for at least two hundred years, yet there are still no definitive answers to the questions of the origin of the malignancy and the underlying mechanism(s) of progression to malignancy. Currently, the field of glioblastoma research is focused on identifying molecular genetic events crucial for gliomagenesis and the consequent development of novel therapeutic agents. Because many of these events were first detected through genetic studies of mammalian cell lines (e.g., NIH/3T3), the first priority for molecularly defined tumors is to determine whether they arise from these or other cell types." - Anonymous Online Contributor
"In addition to the symptoms listed above, signs of cancer that may be present in patients with low-grade glioma include confusion, seizures and visual defects. Other signs that may be present include headaches, visual distortions, visual loss and aphasia. Patients with high-grade glioma may experience seizures and headache." - Anonymous Online Contributor
"Glioma cannot be cured by conventional medical treatments. The key to long-term treatment success is the combined approach of surgery, radiation and chemotherapy. At present, standard treatment cannot result in cure, but it can improve the quality of life of patients; the goal is to reduce the cancer load sufficiently to permit tumour resection with curative intent. It remains to be elucidated whether it is possible at some tumour sites, such as low-grade astrocytomas and glioblastomas, where surgery without post-operative radiotherapy is appropriate, to prevent tumour progression." - Anonymous Online Contributor
"Most cases of glioma are treated by surgery which is followed by radiation therapy. Chemotherapy is used to treat some recurrent glioma and can be administered before and after surgery because of its role in inhibiting tumor cells from regenerating." - Anonymous Online Contributor
"Mebendazole does cross the blood-brain barrier and is active in animal models of human tumors with the IDH mutation but not in cells lacking that mutation. Findings from a recent study, the mouse glioma cell line expressing the IDH1 mutation was more sensitive to mibendazole." - Anonymous Online Contributor
"Results from a recent clinical trial demonstrate that mebendazole is effective in the control of rat brainworm infestations and is very easy to use. Further trials would be desirable." - Anonymous Online Contributor
"For the past few decades of glioma diagnosis, 5 year survival has been more than 80%. However survival at 10 year is about 70% and this is expected to keep on decreasing with time and with advancements in the medical field. Currently there are no guidelines that are used to assess when medical treatment should be started for patients who survive a cancer diagnosis, but a few simple factors are taken into consideration when deciding medical treatment for the patient\n" - Anonymous Online Contributor
"There is a wide range of time to progression after surgery for newly diagnosed primary glioma. A substantial amount of residual disease remains in most patients, even some with high-grade, dedifferentiated, and grade-4 tumors. We observed that residual disease can be quite advanced even 12 months or more after surgery in patients with very low-grade glioma; therefore, it is imperative that patients are diagnosed with anaplastic low-grade gliomas to ensure their disease is adequately treated." - Anonymous Online Contributor
"Mycotic hypersensitivity reactions were encountered in about 9 out of 100 study patients. The dose adjustments were needed in patients with hypersensitivity. In the rest of the patients the dose was adjusted. Mild diarrhea and nausea was reported in the case of severe hypersensitivity. Mild to moderate skin reactions also occurred with the use of the drug. Skin irritation and rashes were reported with repeated use. The adverse effects were generally mild with close follow-up. The duration of treatment was about 11 - 56 days. Mycoses were observed in about 15 out of 100 patients who used the drug for some length of time. The lesions observed were mild and localised and the drug was withdrawn whenever they occurred." - Anonymous Online Contributor
"In a recent study, findings demonstrate that mebendazole is an effective treatment for mild-to-moderate giardiasis, supporting the contention that this drug should be reconsidered for the treatment of mild-to-moderate cases of chronic giardiasis." - Anonymous Online Contributor