Surgical Resection, Pharmacodynamic Assays, and Methimazole for Glioblastoma

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center, Cleveland, OHGlioblastoma+1 MorePharmacodynamic Assays - DiagnosticTest
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing a drug, Methimazole, to see if it can safely treat brain tumors. It will be given to study participants in increasing doses until side effects occur.

Eligible Conditions
  • Glioblastoma
  • Brain Tumor

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: Up to 6 months after treatment

Month 6
Progression Free Survival (PFS) Rate

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

1 Treatment Group

Surgical Resection, Pharmacodynamic Assays, and Methimazole
1 of 1

Experimental Treatment

19 Total Participants · 1 Treatment Group

Primary Treatment: Surgical Resection, Pharmacodynamic Assays, and Methimazole · No Placebo Group · Phase 2

Surgical Resection, Pharmacodynamic Assays, and MethimazoleExperimental Group · 3 Interventions: Pharmacodynamic Assays, Recurrent Glioblastoma Surgical Resection, Methimazole · Intervention Types: DiagnosticTest, Procedure, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Methimazole
2006
Completed Phase 4
~710

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 6 months after treatment

Who is running the clinical trial?

Case Comprehensive Cancer CenterLead Sponsor
432 Previous Clinical Trials
30,463 Total Patients Enrolled
14 Trials studying Glioblastoma
402 Patients Enrolled for Glioblastoma
David Peereboom, MDPrincipal InvestigatorCleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
9 Previous Clinical Trials
384 Total Patients Enrolled
9 Trials studying Glioblastoma
384 Patients Enrolled for Glioblastoma

Eligibility Criteria

Age 18+ · All Participants · 14 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
The doctor thinks you need chemotherapy after your surgery.

Frequently Asked Questions

Are there opportunities for interested parties to join this research initiative?

"According to clinicaltrials.gov, this medical experiment is actively searching for volunteers. The trial was initially listed on March 1st 2023 and has since been revised as of the 9th of that same month." - Anonymous Online Contributor

Unverified Answer

How many volunteers are currently enrolled in this medical experiment?

"Affirmative, the clinicaltrials.gov website mentions that this project is currently seeking participants. This research was initially published on March 1st 2023 and has been revised as recently as September 3rd of the same year. 19 people are required to join at one single site." - Anonymous Online Contributor

Unverified Answer

How perilous is it for people to undergo Surgical Resection, Pharmacodynamic Assays, and Methimazole?

"As this is a Phase 2 trial and there are only data confirming the safety of Surgical Resection, Pharmacodynamic Assays, and Methimazole, it received an assessment score of 2." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.