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Chemotherapy
Combination Chemotherapy for Glioblastoma
Phase 1 & 2
Waitlist Available
Research Sponsored by Atlantic Health System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
No frequent vomiting or other medical condition that would interfere with oral medication administration (e.g., partial bowel obstruction)
No active or uncontrolled infection
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying how well giving two drugs together works in treating patients with glioblastoma multiforme that has returned after treatment.
Who is the study for?
Adults over 18 with recurrent glioblastoma multiforme, a type of brain tumor. They should have a life expectancy of at least 15 weeks and measurable disease. Participants must not have had other cancers (except certain skin cancers or cervical carcinoma in situ) in the past 5 years, be HIV negative, not pregnant or nursing, able to use contraception if fertile, free from severe diseases or psychiatric disorders that could affect study participation.Check my eligibility
What is being tested?
This trial is testing how effective combination chemotherapy is for patients with recurrent glioblastoma multiforme. It's a Phase I/II trial which means it's looking at the right dose to give and then seeing how well it works.See study design
What are the potential side effects?
Chemotherapy can cause side effects like nausea and vomiting, fatigue, hair loss, increased risk of infection due to low blood cell counts, mouth sores, and potential damage to organs such as the liver or kidneys.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I don't have conditions that make it hard for me to take pills.
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I do not have any ongoing or untreated infections.
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I am mostly able to care for myself and remain up and active.
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I have not had a heart attack in the last 6 months.
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I do not have heart failure that needs treatment.
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My glioblastoma has returned and can be measured.
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I am 18 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
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Who is running the clinical trial?
Atlantic Health SystemLead Sponsor
52 Previous Clinical Trials
6,287 Total Patients Enrolled
Michael L. Gruber, MDStudy ChairNYU Langone Health
1 Previous Clinical Trials
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I don't have conditions that make it hard for me to take pills.I haven't had any cancer in the last 5 years, except for certain skin cancers or cervical pre-cancer.I do not have any ongoing or untreated infections.I do not have any severe illnesses that would stop me from joining the study.I am mostly able to care for myself and remain up and active.I have not had a heart attack in the last 6 months.I do not have heart failure that needs treatment.I am still recovering from a major surgery.My glioblastoma has returned and can be measured.I am 18 years old or older.I have never taken temozolomide.I have not had platinum-based chemotherapy before.I am not currently taking sargramostim.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any remaining slots for participants in this clinical experiment?
"As per the information found on clinicaltrials.gov, this particular study is not presently recruiting patients. It was first published back in December of 2000 and last modified in 2013; however, there are 544 other trials with open enrollment at present."
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