This trial is evaluating whether diet and lifestyle program will improve 1 primary outcome and 2 secondary outcomes in patients with Liver Diseases. Measurement will happen over the course of 4 months.
This trial requires 40 total participants across 1 different treatment group
This trial involves a single treatment. Diet And Lifestyle Program is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
"The most common treatment for NASH is caloric restriction or weight reduction. Liver biopsy and/or treatment for nonalcoholic steatohepatitis are not usually recommended without definite clinical evidence of steatohepatitis." - Anonymous Online Contributor
"Between 712,900 and 798,300 individuals in the US are diagnosed with NAFLD or NASH annually, yielding a prevalence for NASH of 2.1-2.5% of adults. The age at diagnosis has decreased over time and has shifted from a female biased to male biased pattern." - Anonymous Online Contributor
"In the great majority of subjects, the cause of NASH was not determined. Among men with a known cause of alcoholism the risk of a NASH diagnosis was found to be lower. NASH is not a homogenous disease, and its cause is likely multifactorial with genetic and environmental factors and complex interactions between them." - Anonymous Online Contributor
"Although [there have been] many reported case series and uncontrolled clinical studies, the treatment of NASH is still in its early stages and there is no established treatment standard. Nevertheless, a number of treatments can lead to histologic clearance with or without symptomatic resolution of hepatologic dysfunction for patients with fibrosis stage 1 or 2; however, some patients with advanced fibrosis stage will experience only minimal or no symptomatic resolution of morbidity; their prognoses [are] strongly related to their underlying medical comorbidities." - Anonymous Online Contributor
"Nonalcoholic steatohepatitis is a collection of signs and symptoms in a person with fatty liver and steatosis. It presents with abnormal blood tests, elevated liver cancer markers, and abdominal imaging studies. A genetic component has been demonstrated to cause the development of nonalcoholic steatohepatitis, particularly in women with a family history of the condition. Obesity also predisposes to development of nonalcoholic steatohepatitis. Nonalcoholic steatohepatitis affects approximately 20 million Americans and is responsible for 1% of all deaths in the United States." - Anonymous Online Contributor
"NASH may rarely present with a picture of acute hepatotoxicity, and hepatotoxicity is an important cause of the death of patients with NASH. The presence of hepatic encephalopathy may be a strong indicator of NASH. Also, the presence of hepatitis is common in cases of NASH, and hepatic encephalopathy may be manifested as a manifestation of this hepatitis." - Anonymous Online Contributor
"The average age of NASH diagnosis is 55 in men and 49 in women in the United States. In the United Kingdom, NASH typically occurs earlier at the age of 42 in men and 30 in women." - Anonymous Online Contributor
"It is unknown (https://www.ncbi.nlm.nih.gov/entrez/genomeview.fcgi?DB=HGNC) how to treat nonalcoholic steatohepatitis. But there is a lot of information that is gathered from the research that has been done to create treatments and new biomarkers for nonalcoholic steatohepatitis.(DOI: 10.1002/ajpj.4277) If you are interested in treating nonalcoholic steatohepatitis, you can use [Power(http://www.withpower.com/clinical-trials) to search trials tailored to your condition." - Anonymous Online Contributor
"Diet and lifestyle program proved to be more effective than placebo in modifying nonalcoholic steatohepatitis features and improving liver function, but not in reducing liver inflammation." - Anonymous Online Contributor
"In more than 45% of patients with non-AFLD fatty liver, NASH is primary. The main factors associated with NASH were insulin resistance and obesity. In patients with non-AFLD NASH, the severity of steatosis is associated with the BMI and insulin resistance." - Anonymous Online Contributor
"There were no significant differences in short-term outcomes in response to placebo and UDCA at 12 weeks of treatment in this small group of patients with nonalcoholic steatohepatitis. Prospective trials are needed to determine the optimal treatment approach in this subset of patients with nonalcoholic steatohepatitis." - Anonymous Online Contributor
"Results of diet and lifestyle programs are similar in general to those of pharmacological treatments, with low rates of adverse effects. People choose treatments based on clinical appropriateness, safety, cost, convenience, and the individual's preference, and with the support of doctors who specialize in treating disease or condition, and not on the efficacy of a program. In a recent study, findings demonstrate that if the objectives of a programme are achievable with the available resources and in a safe manner, then it can provide sustained benefit to a range of people. If possible, it is also advisable to carry out a pilot trial to determine if such objectives are achievable and if they are." - Anonymous Online Contributor