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ACE Inhibitor

Enalapril Pill for High Blood Pressure (H2SPharm Trial)

Q: How many study subjects are enrolled in this research project?

This study is not recruiting patients at the moment, but this could change in the future. According to clinicaltrials.gov, the trial was posted on 7/20/2016 and was last updated on 2/16/2022. There are presently 27 studies for Enalapril Pill admitting participants and 790 trials actively searching for participants with essential <a href="https://www.withpower.com/clinical-trials/hypertension">hypertension</a>.

Q: Does this scientific test only allow volunteers who are 65 years or older?

This particular clinical trial is testing an intervention for patients aged 40 to 65. In contrast, there are 60 trials for people under 18 and 725 trials for senior citizens.

Q: Are people still being asked to participate in this experiment?

This particular trial is not recruiting patients at this moment. However, it was first posted on July 20th 2016 and updated as recently as February 16th 2022. Additionally, there are 27 other trials for Enalapril Pill and 790 studies actively looking for patients with essential <a href="https://www.withpower.com/clinical-trials/hypertension">hypertension</a>.

Q: What type of person do you think would be the best match for this clinical trial?

Eligible participants for this study must have essential <a href="https://www.withpower.com/clinical-trials/hypertension">hypertension</a>, be between 40 and 65 years old. Right now, the trial has 46 open spots.

Q: What are the effects of Enalapril Pill?

Enalapril pills are most commonly used to treat edema, but they can also be effective in treating cerebrovascular accident, therapeutic procedure, and myocardial infarction.

Phase 1 & 2

Waitlist Available

Led By Lacy M Alexander, PhD

Research Sponsored by Penn State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 16 weeks

Awards & highlights

H2SPharm Trial Summary

This trial is studying the effects of different drugs used to treat high blood pressure on blood vessel remodeling.

Eligible Conditions

High Blood Pressure

H2SPharm Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 16 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~16 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 16 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Endothelium Dependent Vasodilation

Secondary outcome measures

Diastolic Blood Pressure

Systolic Blood Pressure

H2SPharm Trial Design

4Treatment groups

Experimental Treatment

Active Control

Group I: Hypertensive - ACE inhibitor with sulfahydrl donor (ACEi +SH)Experimental Treatment1 Intervention

Captopril Pill intervention Blood Pressure ≥140/90 mmHg and <160/110 mmHg

Group II: Hypertensive - ACE inhibitor (ACEi)Experimental Treatment1 Intervention

Enalapril Pill intervention Blood Pressure ≥140/90 mmHg and <160/110 mmHg

Group III: NormotensiveActive Control1 Intervention

Blood Pressure <120/80 mmHg

Group IV: Hypertensive - DiureticActive Control1 Intervention

Hydrochlorothiazide intervention Blood Pressure ≥140/90 mmHg and <160/110 mmHg

Do I qualify?Apply below to find out

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Penn State UniversityLead Sponsor

354 Previous Clinical Trials

125,724 Total Patients Enrolled

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,830 Previous Clinical Trials

47,302,744 Total Patients Enrolled

Lacy M Alexander, PhDPrincipal InvestigatorPenn State University

1 Previous Clinical Trials

15 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many study subjects are enrolled in this research project?

"This study is not recruiting patients at the moment, but this could change in the future. According to clinicaltrials.gov, the trial was posted on 7/20/2016 and was last updated on 2/16/2022. There are presently 27 studies for Enalapril Pill admitting participants and 790 trials actively searching for participants with essential hypertension."

Answered by AI

Does this scientific test only allow volunteers who are 65 years or older?

"This particular clinical trial is testing an intervention for patients aged 40 to 65. In contrast, there are 60 trials for people under 18 and 725 trials for senior citizens."

Answered by AI

Are people still being asked to participate in this experiment?

"This particular trial is not recruiting patients at this moment. However, it was first posted on July 20th 2016 and updated as recently as February 16th 2022. Additionally, there are 27 other trials for Enalapril Pill and 790 studies actively looking for patients with essential hypertension."

Answered by AI

What type of person do you think would be the best match for this clinical trial?

"Eligible participants for this study must have essential hypertension, be between 40 and 65 years old. Right now, the trial has 46 open spots."

Answered by AI

What are the effects of Enalapril Pill?

"Enalapril pills are most commonly used to treat edema, but they can also be effective in treating cerebrovascular accident, therapeutic procedure, and myocardial infarction."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans

Lacy Alexander 2016. "Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03179163.