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Extended-Release Naltrexone + Buprenorphine for Cocaine Use Disorder (CURB-2 Trial)
CURB-2 Trial Summary
This trial tests if XR-NTX & XR-BUP could reduce cocaine use in people with CUD, compared to a placebo.
CURB-2 Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowCURB-2 Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.CURB-2 Trial Design
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Who is running the clinical trial?
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- I agree to use birth control and undergo pregnancy tests if I can conceive.I have not used opioids in the last week and can provide a clean urine sample.I am between 18 and 65 years old.
- Group 1: Drug intervention (XR-NTX+XR-BUP)
- Group 2: Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Does this medical experiment have an upper age limit?
"This medical trial is only for adults aged between 18 and 65; minors have 260 studies available to them, whereas seniors can choose from 653 research programs."
Has the combination of XR-NTX and XR-BUP been ratified by the FDA?
"Our team has rated the safety of Drug Intervention (XR-NTX+ XR-BUP) to be a 2, as this is only at Phase 2. That means that while there have been some studies into its security, none yet support efficacy."
How extensive is the participant enrollment for this scientific investigation?
"Indeed, the information on clinicaltrials.gov reveal that this study is accepting participants. This research endeavor was first posted on March 14th 2023 and last updated on May 2nd 2023; it seeks to recruit 426 patients from two distinct locations."
Are there currently openings in this clinical investigation for participants?
"Affirmative. The details available on clinicaltrials.gov demonstrate that this medical investigation is currently enrolling applicants, with the protocol first uploaded on March 14th 2023 and most recently modified on May 2nd 2023. A total of 426 individuals need to be recruited between two distinct locations."
Am I eligible to enroll in this research endeavor?
"This medical trial requires 426 participants with cocaine use disorder who meet the following conditions: aging between 18 and 65 years, expressing an interest in decreasing or discontinuing their consumption of cocaine, adhering to DSM-5 criteria for moderate/severe CUD (4+ symptoms), providing two urine samples that test positive for cocaine within a 10 day window over 21 days during screening, detailing their past 30-day usage on the Timeline Follow-Back questionnaire, contracepting if female unless incapable of conceiving naturally (e.g., hysterectomy or postmenopause), delivering a sample devoid of opioids as well as declaring no"
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
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