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ACE Inhibitor

Arm A for Type 2 Diabetes

Phase 1 & 2
Waitlist Available
Led By Norman K Hollenberg, MD, PhD
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Type 2 Diabetes Mellitus
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up every 15 minutes for 3 hours
Awards & highlights

Study Summary

This trial will study the effects of salt and Captopril on blood flow in the ophthalmic artery of people with type 2 diabetes.

Eligible Conditions
  • Type 2 Diabetes

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~every 15 minutes for 3 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and every 15 minutes for 3 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in ophthalmic artery blood flow from baseline
Secondary outcome measures
Change in blood pressure from baseline
Change in renal plasma flow (RPF) from baseline

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Arm AActive Control2 Interventions
Captopril 25 mg (Admission 1, Day 1, low salt diet) Matched Placebo (Admission 1, Day 2, low salt diet) Captopril 25 mg (Admission 2, Day 1, high salt diet) Matched Placebo (Admission 2, Day 2, high salt diet)
Group II: CaptoprilPlacebo Group2 Interventions
Matched Placebo (Admission 1, Day 1, low salt diet) Captopril 25 mg (Admission 1, Day 2, low salt diet) Matched Placebo (Admission 2, Day 1, high salt diet) Captopril 25 mg (Admission 2, Day 2, high salt diet)

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalLead Sponsor
1,618 Previous Clinical Trials
11,471,653 Total Patients Enrolled
Ebrahim Barkoudah, M.D.,M.P.H.Study DirectorBrigham and Women's Hospital
Norman K Hollenberg, MD, PhDPrincipal InvestigatorBrigham and Women's Hospital
1 Previous Clinical Trials
22 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Measurement of Eye Blood Flow and Renal Function in Healthy and Diabetic Patients
Norman K. Hollenberg, MD, PhD 2012. "Measurement of Eye Blood Flow and Renal Function in Healthy and Diabetic Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01626469.
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~2 spots leftby May 2025
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