Intravenous Ketamine for Major Depressive Disorder

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Major Depressive DisorderIntravenous Ketamine - Drug
Eligibility
18 - 65
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test whether mindfulness training enhances the effects of ketamine for depression.

Eligible Conditions
  • Major Depressive Disorder

Treatment Effectiveness

Study Objectives

2 Primary · 5 Secondary · Reporting Duration: infusion +40min

30 days post-intervention
Daily Spiritual Experience Scale
Mindful Attention Awareness Scale
Montgomery-Asberg Depression Rating Scale
Quick Inventory of Depressive Symptoms
modified Hamilton Depression Rating Scale
80min post-infusion
State Mindfulness Scale
Day 1
Dual probe video task
Sustained Attention Response Task (SART) omission errors
Sustained Attention Response Task (SART) self-reported task focus
infusion +40min
Hood Mysticism Scale
infusion +80min
Awe Experience Scale

Trial Safety

Trial Design

2 Treatment Groups

Intravenous Ketamine + Academic Exercises
1 of 2
Intravenous Ketamine + Mindfulness Exercises
1 of 2

Active Control

Experimental Treatment

60 Total Participants · 2 Treatment Groups

Primary Treatment: Intravenous Ketamine · No Placebo Group · Phase 1 & 2

Intravenous Ketamine + Mindfulness ExercisesExperimental Group · 2 Interventions: Intravenous Ketamine, Brief Mindfulness Exercises · Intervention Types: Drug, Behavioral
Intravenous Ketamine + Academic ExercisesActiveComparator Group · 2 Interventions: Intravenous Ketamine, Academic Exercises · Intervention Types: Drug, Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: infusion +40min

Who is running the clinical trial?

Rebecca PriceLead Sponsor
5 Previous Clinical Trials
590 Total Patients Enrolled
Rebecca Price, PhDPrincipal InvestigatorUniversity of Pittsburgh

Eligibility Criteria

Age 18 - 65 · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are between the ages of 18 and 65 years.
You have a score of 14 or higher on the Hamilton Depression Rating Scale (modified Ham-D).

Who else is applying?

What state do they live in?
North Carolina50.0%
Louisiana50.0%
How old are they?
18 - 65100.0%
What site did they apply to?
Western Psychiatric Institute and Clinic100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%