CLINICAL TRIAL

Oral Rehydration Solution 2 for Dehydration

Recruiting · 18 - 65 · All Sexes · Chicago, IL

Hydration Dynamics and Influence of Beverage Composition

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About the trial for Dehydration

Eligible Conditions
Dehydration · Hydration · Fluid Retention

Treatment Groups

This trial involves 3 different treatments. Oral Rehydration Solution 2 is the primary treatment being studied. Participants will be divided into 2 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.

Experimental Group 1
Oral Rehydration Solution 2
BIOLOGICAL
Experimental Group 2
Oral Rehydration Solution 1
BIOLOGICAL
Control Group 3
Placebo
BIOLOGICAL

Eligibility

This trial is for patients born any sex between 18 and 65 years old. There are 8 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Have a BMI of 18.5 to 29.9 kg/m2.
Be normotensive (<120/80 mm Hg).
Must be able to speak and read English.
Be physically active or a regular exerciser but be able to abstain from exercise for 48 h prior to each study trial.
Fast for at least 8 hours prior to and through the study trial.
Be able to abstain from alcohol for 48 h prior to each study.
Be able to abstain from caffeine for 24 h prior to each study.
If female, must have regular menstrual cycles, that are > 27 days and < 35 days in length.
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 2 hours
Screening: ~3 weeks
Treatment: Varies
Reporting: 2 hours
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 2 hours.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Oral Rehydration Solution 2 will improve 3 primary outcomes and 6 secondary outcomes in patients with Dehydration. Measurement will happen over the course of 2 hours.

Rate of appearance of deuterium in the plasma for oral rehydration solution 1.
2 HOURS
Measure the rate of fluid uptake by the gut using appearance of deuterium oxide, or D2O, in the blood after ingesting a fixed volume of placebo.
2 HOURS
Change in plasma volume for placebo
2 HOURS
Increase in plasma volume (water content of the blood) following ingestion of beverage
2 HOURS
Change in plasma volume for oral rehydration solution 1
2 HOURS
Increase in plasma volume (water content of the blood) following ingestion of beverage
2 HOURS
Rate of appearance of deuterium in the plasma for oral rehydration solution 2.
2 HOURS
Measure the rate of fluid uptake by the gut using appearance of deuterium oxide, or D2O, in the blood after ingesting a fixed volume of placebo.
2 HOURS
Change in plasma volume for oral rehydration solution 2
2 HOURS
Increase in plasma volume (water content of the blood) following ingestion of beverage
2 HOURS
Rate of appearance of deuterium in the plasma for placebo
2 HOURS
Measure the rate of fluid uptake by the gut using appearance of deuterium oxide, or D2O, in the blood after ingesting a fixed volume of placebo.
2 HOURS
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Who is running the study

Principal Investigator
C. A. H.
Prof. Craig A. Horswill, Clinical Associate Professor
University of Illinois at Chicago

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of dehydration?

A large red eye is a common, benign sign of dehydration. Patients may consider checking their eye fluid volume if they notice this eye symptom, and seek medical help if it persists. Dehydration can also result from a severe burn, kidney failure, or severe diarrhea. Patients with diabetes suffer from chronic dehydration. Older patients with decreased kidney function and people with chronic heart failure may also be dehydrated. More severe dehydration may be accompanied by tachycardia, sweating, nausea, dizziness and vomiting. The skin is dry and pale in patients with severe dehydration, whereas a dry and pale skin is an expected sign of burn patients. The skin may turn blue if the person inhales nitrite or nitrous oxide gas.

Anonymous Patient Answer

Can dehydration be cured?

[Dehydration caused in rats by drinking water, is not cured by drinking water. It is advisable, whenever possible, to drink enough water to compensate for the lost volume and the electrolyte levels are re-established when possible. It is also necessary to correct dehydration and electrolyte imbalance if it is present. For acute dehydration, one method to use in emergencies is to take salty solution from the kitchen to compensate for the deficit of water. Drinking salty solution may also suffice for acute dehydration, but intravenous saline is often safer and more helpful. Oral rehydration therapy can also be effective. For chronic dehydration, one of the main aims is to treat malnutrition, which includes avoiding over-exhaustion of energy intake.

Anonymous Patient Answer

What is dehydration?

Dehydration affects almost every organ in the body. The kidneys deal with fluid that is not retained as water in order to regulate body fluids and maintain water balance by regulating the hypothalamic fluids counter regulatory systems. It can also impact the function of the heart by affecting the cardiac contractility and cause symptoms such as fatigue, shortness of breath, and rapid heartbeat. The lungs also have a part to play in dehydration because it affects the pulmonary pressure, which is responsible for pushing the oxygen and the carbon dioxide into the bloodstream. A healthy person is able to retain approximately 400 ml in their fluids daily, so the amount that a person may lose is usually not harmful.

Anonymous Patient Answer

What are common treatments for dehydration?

Hydration is necessary and often complicated by dehydration, which in turn may cause thirst and cause one to be anxious. Oral rehydration solution is one of the best options for hydration to be used by caregivers in the emergency room. Aspirin may be recommended if at high danger, and, although less likely, some form of IV fluids may be injected if at need. In all patients, the key thing is to maintain adequate fluids and to keep their electrolytes normal.

Anonymous Patient Answer

What causes dehydration?

Approximately half of adults admitted to intensive care units have dehydration. Dehydration is also common in older patients irrespective of ICU stay. We advocate the use of oral rehydration therapy if warranted. A prospective study to explore the relationship is now proposed.

Anonymous Patient Answer

How many people get dehydration a year in the United States?

The rates of hydration deficiency are high, with an estimated 1 in 16 (6%) population for the United States. This is likely a public health problem with the potential for a negative impact on health and welfare. In addition, there is no consensus in the healthcare community regarding recommendations for hydration, particularly for critically ill patients.

Anonymous Patient Answer

How does oral rehydration solution 2 work?

Oral rehydration solution 2 as described in the WHO manual is effective for the management of diarrhoea. One to two liters is adequate for water and electrolyte replacement. Lactated Ringer's solution is more effective and safe when administered more rapidly. The volume of Ringer's solution lost before rehydration should be considered in calculating total fluid requirement.

Anonymous Patient Answer

What are the latest developments in oral rehydration solution 2 for therapeutic use?

The recent developments in oral rehydration solution 2 were shown to minimize the problems faced by earlier Osmotic solutions: they reduce the time required for the child to take the required dose and help maintain the desired fluid volume despite the reduction in sodium, which is a key benefit of ORS2.

Anonymous Patient Answer

What is the latest research for dehydration?

There are few studies that describe the clinical usefulness of dehydration. In those that do, patients tend to benefit. However, in the absence of reliable studies, doctors must rely on anecdotal evidence to assess dehydration. To encourage a proactive approach to dehydration, doctors should [encourage patients to manage dehydration in a systematic way] and help patients [create a self-care plan that includes hydrational measures to manage dehydration symptoms appropriately.

Anonymous Patient Answer

Is oral rehydration solution 2 safe for people?

Oral rehydration solution 2 is safe and may reduce hospital admissions in patients admitted to hospitals that have a significant water deficit and hyponatraemia. In a recent study, findings suggests that oral rehydration solution 2 is safe for people who are hospitalized.

Anonymous Patient Answer

What are the common side effects of oral rehydration solution 2?

Results from a recent clinical trial found that most patients were able to tolerate ORS 2 without concern about its side effects. Most patients were satisfied about the taste and appearance of the ORS 2.

Anonymous Patient Answer

Who should consider clinical trials for dehydration?

Patients who use OTC or non-OTC products commonly do not report their use of such medication to their clinicians, suggesting low awareness of dehydration, and potentially undertreatment. Dehydration is more common in females. A review of dehydration prevention in the elderly may be warranted, especially if no-cost, non-OTC products are being used.

Anonymous Patient Answer
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