30 Participants Needed

New CT Scan Method for Lung Imaging

SW
RS
Overseen ByRadiology Studies
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: University of Wisconsin, Madison
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new method of using CT scans to examine the lungs without contrast dye. The researchers aim to determine if this approach provides better details about lung blood flow compared to standard CT scans. Individuals already scheduled for a CT scan of the head, neck, chest, abdomen, pelvis, or limbs may be suitable candidates. Participation helps assess the effectiveness of this new method. As a Phase 2 trial, the research focuses on evaluating the treatment's effectiveness in an initial, smaller group.

What prior data suggests that this new CT scan method is safe for lung imaging?

Research has shown that the new CT scan method for lung imaging is generally safe. CT scans are commonly used to check for lung cancer and are usually well-tolerated. However, studies suggest that frequent CT scans could increase the risk of developing cancer later on. This new method aims to lower that risk by avoiding contrast agents, which can sometimes cause side effects.

Since this trial is in Phase 2, earlier tests have already demonstrated some safety. Participants in this trial will undergo a 30-minute chest CT scan, a standard procedure. While complete safety details for this new method are not yet available, avoiding contrast agents might reduce the chance of side effects.12345

Why are researchers excited about this trial?

Researchers are excited about the new CT scan method for lung imaging because it aims to provide clearer and more detailed images of the lungs compared to traditional CT scans. This could enhance the ability to detect early signs of lung disease and abnormalities with greater accuracy. Additionally, this method might reduce the amount of radiation exposure to patients, which is a significant concern with standard CT scans. By improving image clarity and safety, this technique has the potential to revolutionize lung diagnostics and patient outcomes.

What evidence suggests that this new CT scan method is effective for lung imaging?

Research has shown that new CT scan technologies have made diagnosing lung issues easier and more accurate. Studies have found that these advancements help doctors better detect and monitor lung conditions, such as determining if a nodule (a small lump) is growing, which can indicate cancer. Additionally, these advanced CT scans can enhance the safety and success of lung treatments. In this trial, participants will undergo this new type of CT scan, which provides detailed information about blood flow in the lungs without requiring a contrast dye, offering clearer insights than regular CT scans. These advancements suggest that the new method could be a valuable tool in lung imaging.13567

Who Is on the Research Team?

MS

Matthew Smith, MD, PhD

Principal Investigator

University of Wisconsin, Madison

Are You a Good Fit for This Trial?

This trial is for individuals who require a chest CT scan. The study is evaluating a new contrast-free imaging method to see if it provides more information about lung perfusion compared to the standard CT imaging.

Inclusion Criteria

Able to sign and date the informed consent form
Will undergo a clinically-indicated CT exam of the head, neck, chest, abdomen, pelvis, or extremities
I am 18 years old or older.

Exclusion Criteria

Pregnant or lactating
In need of urgent or emergent care
Have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the participant

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

CT Scan

Participants undergo a 30 minute chest CT to evaluate the X-ray Pulsatility Index (XPI) using dynamic CT imaging methods.

30 minutes
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the CT scan

1-2 weeks

What Are the Treatments Tested in This Trial?

Trial Overview The intervention being studied is a new computed tomography (CT) lung perfusion imaging technique that does not use contrast agents. Participants will undergo a 30-minute chest CT using this new method.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: CT scanExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Wisconsin, Madison

Lead Sponsor

Trials
1,249
Recruited
3,255,000+

Citations

Advancements in Imaging Technologies for the Diagnosis of ...Advancements in imaging technologies have redefined pulmonary medicine, with increased diagnostic accuracy and improved clinical outcomes.
Explainable AI for lung cancer detection via a custom CNN ...introduced a DL-enabled SVM-based cancer diagnostic model for detecting lung cancer in CT scans. The model achieves 94% accuracy in early-stage ...
Improved CT Imaging Accuracy & Precision in Lung CancerBy tracking changes in nodule size over time and calculating VDT, clinicians gain a more reliable method to predict malignancy, supporting more ...
Action plan for an international imaging framework ...Reduction in lung cancer mortality is achievable through low dose computed tomography (LDCT) screening in high-risk individuals.
Advances in CT-based lung function imaging for thoracic ...In conclusion, CT-based lung function imaging holds significant promise for improving the effectiveness and safety of thoracic radiotherapy.
Projected Lifetime Cancer Risks From Current Computed ...This risk model projects how many future cancers in the United States could result from annual computed tomography examinations.
Enhancing safety in CT-guided lung biopsies: correlation of ...This study aimed to evaluate whether minimum-intensity projection (MinIP) images could predict complications in CT-guided lung biopsies.
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