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Cancer Vaccine

SBRT for Colorectal Cancer

Q: For what purpose is SBRT most often employed?

<p>SBRT is a common treatment for locally advanced non-<a href="https://www.withpower.com/clinical-trials/small-cell-lung-cancer">small cell lung cancer</a>, but can also target other types of cancers including metastatic <a href="https://www.withpower.com/clinical-trials/bladder-cancer">bladder cancer</a>, lung cancers, and refractory fallopian tube carcinoma.</p>

Phase 1 & 2

Waitlist Available

Research Sponsored by ImmunityBio, Inc.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

Study Summary

This trial is testing a new vaccine for colorectal cancer against the current standard of care to see if it is more effective.

Eligible Conditions

Colorectal Cancer

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Incidence of treatment-emergent AEs and SAEs, graded using the NCI CTCAE Version 4.03

Overall Response Rate, as determined by the percentage of patients achieving Partial or Complete Response per RECIST 1.1

Progression Free Survival from baseline to progression, per RECIST 1.1

Secondary outcome measures

DCR for Phase 1b, Phase 2 Randomized, and Phase 2 Single Arm Component

DOR for Phase 1b, Phase 2 Randomized, and Phase 2 Single Arm Component

ORR for Phase 1b and Phase 2 Randomized Component

+3 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: NANT Colorectal Cancer (CRC) VaccineExperimental Treatment20 Interventions

A combination of agents will be administered to subjects in this study: Aldoxorubicin HCI, ETBX-011, ETBX-021, ETBX-051, ETBX-061, GI-4000, GI-6207, GI-6301, haNK, N-803, Avelumab, Capecitabine, Cetuximab, Cyclophosphamide, 5-Fluorouracil, Leucovorin, Nab-paclitaxel, Oxaliplatin, Regorafenib, SBRT.

Group II: RegorafenibActive Control1 Intervention

In subjects with metastatic CRC who have been previously treated with standard-of-care (SOC) therapy.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

SBRT

2014

Completed Phase 2

~1060

Cyclophosphamide

1995

Completed Phase 3

~3780

Capecitabine

2013

Completed Phase 3

~3420

GI-4000

2006

Completed Phase 2

~180

5-Fluorouracil

2012

Completed Phase 3

~7800

ALT-803

2016

Completed Phase 2

~170

Nab-paclitaxel

2014

Completed Phase 3

~2030

Avelumab

2018

Completed Phase 2

~2450

Leucovorin

2005

Completed Phase 4

~5730

Oxaliplatin

2011

Completed Phase 4

~2560

Regorafenib

2014

Completed Phase 2

~1580

ETBX-011

2017

Completed Phase 2

~10

Cetuximab

2011

Completed Phase 3

~2480

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

ImmunityBio, Inc.Lead Sponsor

63 Previous Clinical Trials

4,804 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

For what purpose is SBRT most often employed?

"SBRT is a common treatment for locally advanced non-small cell lung cancer, but can also target other types of cancers including metastatic bladder cancer, lung cancers, and refractory fallopian tube carcinoma."

Answered by AI

How many people are chosen to participate in this test?

"Unfortunately, this study is no longer recruiting patients. Although it was last updated on March 28th, 2022, the clinical trial was originally posted on May 25th, 2018. However, if you are still interested in participating in studies related to metastatic colorectal cancer (crc) or SBRT, there are 912 and 2522 trials respectively that are still looking for volunteers."

Answered by AI

What is the aim of this research project?

"The primary goal of this one-year long clinical trial is to track Progression Free Survival from start to finish. Additionally, the study hopes to measure Overall Survival, Disease Control Rate, and Duration or Response in order to assess the effectiveness of the proposed intervention."

Answered by AI

Are we still looking for more participants for this clinical trial?

"Unfortunately, this particular clinical trial is no longer recruiting patients. The study was first posted on May 25th, 2018 and received its most recent update on March 28th, 2022. However, there are presently 912 other trials actively looking for patients with metastatic colorectal cancer (crc) and 2522 studies for SBRT that need participants."

Answered by AI

Are there any other instances in which SBRT has been studied?

"SBRT is being studied in 2522 different clinical trials. Of these, 605 are Phase 3 studies. Many of the SBRT clinical trials are based in Guangzhou, Guangdong; however, there are 96572 locations running these sorts of medical experiments."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

QUILT 3.071: NANT Colorectal Cancer (CRC) Vaccine

2018. "QUILT 3.071: NANT Colorectal Cancer (CRC) Vaccine". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03563157.