CLINICAL TRIAL

[89Zr]Panitumumab PET-MRI for Colorectal Cancer

Newly Diagnosed
Recruiting · 18+ · All Sexes · Birmingham, AL

This study is evaluating whether a PET scan may be useful for determining if lymph nodes are affected by colon cancer.

See full description

About the trial for Colorectal Cancer

Eligible Conditions
Metastatic Colon Cancer · Colorectal Neoplasms

Treatment Groups

This trial involves 2 different treatments. [89Zr]Panitumumab PET-MRI is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
[89Zr]Panitumumab PET-MRI
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. You must have received newly diagnosed for Colorectal Cancer or the other condition listed above. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
You must be at least 19 years old to enter this establishment. show original
Colon cancer is a cancer that starts in the colon show original
Scheduled to undergo surgical resection
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 12 months
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 12 months.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether [89Zr]Panitumumab PET-MRI will improve 1 primary outcome in patients with Colorectal Cancer. Measurement will happen over the course of 12 months.

Image Quality
12 MONTHS
Diagnostic image quality of [89Zr]Panitumumab PET imaging in patients with newly diagnosed colon cancer with nodal involvement. Standardized Uptake Values (SUVs) will be measured.
12 MONTHS

Who is running the study

Principal Investigator
S. E. L.
Suzanne E. Lapi, PhD
University of Alabama at Birmingham

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can colorectal cancer be cured?

The incidence of new cases of CRC in Poland for the year 2013 were 1,900 new CRC cases with 545 cancers in men and 1,335 new cases of CRCs with 359 in women in Poland. However, 5.5% of the new CRC cases were due to adenomatous polyps. Only 19·3% had invasive colorectal cancers. The average age of CRC patients was 65.6 years. In men the average age of new primary CRC cases was 63 years old while in women it was 61·7 years old.

Anonymous Patient Answer

What is colorectal cancer?

The incidence of [colo[rectal cancer](https://www.withpower.com/clinical-trials/rectal-cancer)](https://www.withpower.com/clinical-trials/colorectal-cancer) in the US dramatically increased between 1991 and 1999 by 18%, leading to a more than 30% increase in colorectal cancer incidence between 1993 and 2002 in the US. The increase was more pronounced in men than in women. Although the increase was driven primarily by colon cancer, the increase occurred in rectum cancer as well. The increase was particularly evident among colon and rectal cancer in Hispanics and White, black, and Hispanic men. Colorectal cancer was one of the top 10 most common causes of cancer death in the US in 2012.

Anonymous Patient Answer

What are common treatments for colorectal cancer?

In the past decades, numerous agents have been developed for treatment of colorectal cancer and various novel agents are still in the development stage. However, the effectiveness of chemotherapy agents for colorectal cancer remains limited, and the development of more potent chemotherapeutic drugs is still needed. Chemotherapeutic agents commonly used for colorectal cancer include fluorouracil, 5-fluorouracil, cisplatin, irinotecan, docetaxel, capecitabine and oxaliplatin.

Anonymous Patient Answer

What causes colorectal cancer?

A combination of environmental and genetic factors influence CRC occurrence. For CRC, the primary risk factors are age at diagnosis and male sex, whereas smoking is an important modifiable factor.

Anonymous Patient Answer

How many people get colorectal cancer a year in the United States?

Around 16,100 people die of [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) per year, making it the third most frequent cause of cancer-related death in the US. Approximately 50% of colorectal cancers are diagnosed at an early stage. These data strongly support the need to increase the rate of colonoscopy in the US population, as an important tool in the discovery of colorectal cancer.

Anonymous Patient Answer

What are the signs of colorectal cancer?

It is important for patients to recognize their initial symptoms before medical treatment. Among these, rectal bleeding and anemia are the most common, but abdominal pain, swelling or a palpable mass are more subtle. All of these signs are associated with colorectal cancer.

Anonymous Patient Answer

Is [89zr]panitumumab pet-mri safe for people?

A PET-derived target dose of up to 25 mCi (80 megavolume) given as a repeated sigmoidoscopy scan per week is well tolerated both with and without (131)I.

Anonymous Patient Answer

Who should consider clinical trials for colorectal cancer?

Clinical research activities are expanding to address many facets of cancer care, and colorectal cancer constitutes another area in which significant progress is needed. Therefore, we believe that patients and clinicians should be informed about potential limitations and the implications of clinical research.

Anonymous Patient Answer

Have there been other clinical trials involving [89zr]panitumumab pet-mri?

[89zr]Panitumumab PET was found to be technically feasible with a short, low-molecular-weight peptide, and it could be a helpful tool for evaluating the tumour response to [89zr]panitumumab PET-mri in colorectal cancer.

Anonymous Patient Answer

How quickly does colorectal cancer spread?

This illustrates that most people spread colorectal cancer within 2 years. This data may help develop the tools of prevention. A good prevention option will be a screening for colorectal cancer every one to three years, or more regularly until the patient is 75.

Anonymous Patient Answer

What is the survival rate for colorectal cancer?

The survival rate for colorectal cancer is approximately 68% and depends on the stage. Overall, the 5-year and 10-year survival rates are 52% and 45%, respectively. Survival rate is lower for patients presenting with a nodal or lymph node metastasis. The 5-year survival rates for patients with stage IV colorectal cancer are 25%, compared to 80% for stage II colorectal cancer. The 5-year mortality rate for stage I colorectal cancer is about 13%, and nearly 80% of patients survive beyond 10 years.

Anonymous Patient Answer

Has [89zr]panitumumab pet-mri proven to be more effective than a placebo?

Results from a recent clinical trial suggest that [(89)Zr]panitumumab PET-MRI may offer a promising method to provide non-invasive imaging of tumor response to pembrolizumab treatment. ClinicalTrials.gov: NCT00881345.

Anonymous Patient Answer
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